CLIP1 antibody (C-Term)

Catalog No. ABIN499641

Product Details anti-CLIP1 Antibody

Target: CLIP1 (CAP-GLY Domain Containing Linker Protein 1 (CLIP1))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CLIP1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Specificity: This antibody reacts to CLIP170.

Purification: Affinity chromatography purified via peptide column

Immunogen: CLIP170 antibody was raised against a 17 amino acid peptide from near the carboxy terminus of human CLIP170.

Isotype: IgG

Application Details

Application Notes: ELISA. Western Blot: CLIP170 antibody can be used for detection of CLIP170 at 0.5 - 1 μg/mL. Immunofluorescence.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store the antibody undiluted at 2-8 °C.

Target Details for CLIP1

Target: CLIP1 (CAP-GLY Domain Containing Linker Protein 1 (CLIP1))

Alternative Name: CLIP1 / Restin (CLIP1 Products)

Synonyms: RSN antibody, CLIP1 antibody, clip170 antibody, clip-170 antibody, CLIP antibody, CLIP-170 antibody, CLIP170 antibody, CYLN1 antibody, 1110007I12Rik antibody, 4631429H07Rik antibody, AV017631 antibody, C81039 antibody, Clip50 antibody, Rsn antibody, mKIAA4046 antibody, restin antibody, CAP-Gly domain containing linker protein 1 antibody, CAP-Gly domain-containing linker protein 1 antibody, CAP-Gly domain containing linker protein 1 L homeolog antibody, CAP-GLY domain containing linker protein 1b antibody, CAP-GLY domain containing linker protein 1 antibody, CLIP1 antibody, LOC100075022 antibody, clip1 antibody, clip1.L antibody, clip1b antibody, Clip1 antibody

Background: CLIP170 was initially identified as a new type of intermediate filament associated protein that is highly expressed in Reed-Sternberg cells, the tumoral cells diagnostic for Hodgkin's disease. Later experiments showed that it is located at microtubule plus ends and is required for the binding of endocytic carrier vesicles. CLIP170 has also been suggested to act with LIS1, a protein implicated in brain development, to regulate dynein/dynactin binding microtubules. Other studies suggest that CLIP170 can influence the formation of lamellipodia and cell invasion by invasive breast cancer cells by regulating the release of kinesin and IQGAP1 from a complex of those proteins, CLIP170 and Rac1. At least two isoforms of CLIP170 are known to exist.Synonyms: CAP-Gly domain-containing linker protein 1, CLIP-170, CYLN1, Cytoplasmic linker protein 1, Cytoplasmic linker protein 170 alpha-2, RSN, Reed-Sternberg intermediate filament-associated protein

Gene ID: 6249

NCBI Accession: NP_002947

UniProt: P30622

Pathways: Microtubule Dynamics