Death-Domain Associated Protein (DAXX) (C-Term) antibody

Details for Product No. ABIN499714
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Antigen
Synonyms im:6905684, LOC100226911, BING2, DAP6, EAP1
Epitope
C-Term
(23), (17), (17), (17), (13), (13), (11), (6), (6), (5), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(197), (64), (52), (48), (37), (24), (5), (4)
Host
Rabbit
(170), (34)
Clonality
Polyclonal
Conjugate
Un-conjugated
(8), (8), (8), (6), (6), (6), (6), (6), (6), (6), (6), (2), (2), (2)
Application
ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blotting (WB)
(138), (66), (60), (38), (37), (36), (22), (10), (9), (8), (6), (2), (1), (1)
Pubmed 2 references available
Quantity 0.1 mg
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
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Catalog No. ABIN499714
401.50 $
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Immunogen Human Daxx (C-Terminus) Peptide
Isotype IgG
Specificity Daxx antibody was raised against a peptide corresponding to amino acids near the carboxy- terminus of human Daxx.
Purification DEAE
Alternative Name DAXX
Background Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNFR1 and Fas. Cell death signals are transduced by death domain (DD)- containing adapter molecules and members of the ICE/CED-3 protease family. A novel DD- containing molecule was recently cloned from mouse, human and monkey and designated Daxx. Daxx binds specifically to the Fas death domain and enhances Fas induced apoptosis and activates the Jun N-terminal kinase (JNK) pathway. Daxx is widely expressed in fetal and adult human and mouse tissues indicating its important function in Fas signaling pathways.
Alternate names: BING2, DAP6, Death domain-associated protein 6, EAP1, ETS1-associated protein 1, Fas death domain-associated protein
Gene ID 1616
NCBI Accession NP_001135441
UniProt Q9UER7
Application Notes ELISA. Western Blot: 1–2 μg/ml. A 120 kDa major band can be detected. Immunocytochemistry. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer PBS containing 0.02% sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8°C.
Expiry Date 12 months
Background publications Yang, Khosravi-Far, Chang et al.: "Daxx, a novel Fas-binding protein that activates JNK and apoptosis." in: Cell, Vol. 89, Issue 7, pp. 1067-76, 1997 (PubMed).

Kiriakidou, Driscoll, Lopez-Guisa et al.: "Cloning and expression of primate Daxx cDNAs and mapping of the human gene to chromosome 6p21.3 in the MHC region." in: DNA and cell biology, Vol. 16, Issue 11, pp. 1289-98, 1998 (PubMed).

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