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serine/threonine Kinase 17b (STK17B) (C-Term) antibody

Details for Product No. ABIN499770
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Antigen
Synonyms zgc:65989, STK17B, DRAK2, Drak2, 3110009A03Rik, AI120141
Epitope
C-Term
(28), (9), (9), (8), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(77), (22), (20), (13), (12), (12)
Host
Rabbit
(66), (9), (4)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blotting (WB)
(57), (29), (20), (11), (11), (10), (6), (1), (1), (1)
Pubmed 1 reference available
Quantity 0.1 mg
Shipping to United States (Change)
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Catalog No. ABIN499770
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Immunogen Human DRAK2 (C-Terminus) Peptide (AP30303CP-N)
Isotype IgG
Specificity DRAK2 antibody was raised against a peptide corresponding to amino acids 351 to 365 of human DRAK2. It has no cross responses to DAP or ZIP kinases.
Purification Ion exchange chromatography
Alternative Name STK17B / DRAK2
Background Apoptosis is mediated by death domain containing adapter molecules and a caspase family of proteases. Certain serine/threonine protein kinases, such as ASK-1 and RIP, are mediators of apoptosis. Two novel serine/threonine kinases that induce apoptosis were recently identified and designated DRAK1 and DRAK2 (for DAP kinase-related apoptosis- inducing protein kinases) (1). DRAKs contain an N-terminal kinase domain and a C-terminal regulation domain. Overexpression of DRAK2 induces apoptosis. DRAKs have high sequence homology to DAP and ZIP kinases, and they represent a novel family of serine/threonine kinases, which mediates apoptosis through their catalytic activities. DRAK2 is located in nucleus and the messenger RNA was ubiquitously expressed in human tissues (1).
Alternate names: DAP kinase-related apoptosis-inducing protein kinase 2, Serine/threonine-protein kinase 17B
Gene ID 9262
NCBI Accession AB011421
UniProt O94768
Application Notes ELISA. Western Blot: 1/500 to 1/1000. An approximately 45 kDa band can be detected. Theapproximately 70 kDa band is probably non-related to DRAK2 although it is peptideblockable. Immunocytochemistry. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer PBS containing 0.02% sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8°C.
Expiry Date 12 months
Background publications Sanjo, Kawai, Akira: "DRAKs, novel serine/threonine kinases related to death-associated protein kinase that trigger apoptosis." in: The Journal of biological chemistry, Vol. 273, Issue 44, pp. 29066-71, 1998 (PubMed).

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