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Details for Product No. ABIN499806

Transmembrane Channel-Like 6 (TMC6) (N-Term) antibody

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Antigen
Synonyms EV1, EVER1, EVIN1, LAK-4P, D11Ertd204e, zgc:92610, MGC83549, ever1
Epitope
»Alternatives N-Term
Reactivity
»Alternatives Human, Mouse (Murine), Rat (Rattus)
Host
»Alternatives Rabbit
Clonality Polyclonal
Application
»Alternatives ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
Pubmed 4 references available
Catalog no. ABIN499806
Quantity 0.1 mg
Price
390.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 8 Business Days
Immunogen EVER1 antibody was raised against a 14 amino acid peptide from near the amino terminus of human EVER1. (AP30321CP-N)
Isotype IgG
Specificity This antibody reacts to EVER1.
Purification Affinity chromatography purified via peptide column
Alternative Name TMC6 / EVER1
Background Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes, EVER1 and EVER2, located on chromosome 17q25.3. Both of these genes encode integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. Both EVER1 and EVER2 are members of the transmembrane channel-like (TMC) protein family. EVER1 possesses eight trans- membrane domains and two leucine zipper motifs. EVER1 and EVER2 form a complex and interact with the zinc transporter 1 (ZnT-1), suggesting that EVER1 and EVER2 act to regulate cellular zinc balance. At least four isoforms of EVER1 are known to exist. This EVER1 antibody does not cross-react with EVER2.
Alternate names: EVIN1, Epidermodysplasia verruciformis protein 1, LAK-4, Transmembrane channel-like protein 6
Gene ID 11322
NCBI Accession AAM44452
UniProt Q7Z403
Application Notes ELISA. Western Blot: 1 – 2 μg/ml. Immunohistochemistry. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer PBS containing 0.02% sodium azide.
Preservative Sodium azide
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8°C.
Expiry Date 12 months
Background publications Majewski, Jabłońska, Orth: "Epidermodysplasia verruciformis. Immunological and nonimmunological surveillance mechanisms: role in tumor progression." in: Clinics in dermatology, Vol. 15, Issue 3, pp. 321-34, 1997 (PubMed).

Ramoz, Rueda, Bouadjar et al.: "Mutations in two adjacent novel genes are associated with epidermodysplasia verruciformis." in: Nature genetics, Vol. 32, Issue 4, pp. 579-81, 2002 (PubMed).

Keresztes, Mutai, Heller: "TMC and EVER genes belong to a larger novel family, the TMC gene family encoding transmembrane proteins." in: BMC genomics, Vol. 4, Issue 1, pp. 24, 2003 (PubMed).

Lazarczyk, Pons, Mendoza et al.: "Regulation of cellular zinc balance as a potential mechanism of EVER-mediated protection against pathogenesis by cutaneous oncogenic human papillomaviruses." in: The Journal of experimental medicine, Vol. 205, Issue 1, pp. 35-42, 2008 (PubMed).

Alternatives for antigen "Transmembrane Channel-Like 6 (TMC6)", type "Antibodies"
Hosts (27)
Reactivities (26), (16), (8)
Applications (27), (17), (17), (7), (1)
Epitopes (10), (4), (3), (2), (1), (1), (1), (1)
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