HAAO antibody (N-Term)

Catalog No. ABIN499940

The Rabbit Polyclonal anti-HAAO antibody is suitable to detect HAAO in samples from Human, Mouse and Rat. It has been validated for WB, IHC (p) and EIA.

Quick Overview for HAAO antibody (N-Term) (ABIN499940)

Target: HAAO (3-hydroxyanthranilate 3,4-Dioxygenase (HAAO))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HAAO antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Product Details anti-HAAO Antibody

Binding Specificity: N-Term

Purification: Affinity chromatography purified via peptide column

Immunogen: HAAO antibody was raised against a 17 amino acid peptide near the amino terminus of human HAAO.

Isotype: IgG

Application Details

Application Notes: ELISA. Western Blot: 1 - 2 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store the antibody undiluted at 2-8 °C.

Target Details for HAAO

Target: HAAO (3-hydroxyanthranilate 3,4-Dioxygenase (HAAO))

Alternative Name: HAAO

Background: HAAO (3-Hydroxyanthranilate 3,4-dioxygenase) is a monomeric cytosolic protein of the family of intramolecular dioxygenases containing non-heme ferrous iron. It is widely distributed in peripheral organs, such as liver and kidney, and is present in low amounts in the central nervous system. This enzyme participates in tryptophan metabolism. It employs one cofactor, iron. HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurological and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN. Furthermore, recent study shows that HAAO are excellent candidate biomarkers for detecting ovarian cancer.Synonyms: 3-HAO, 3-hydroxyanthranilate 3, 3-hydroxyanthranilate oxygenase, 3-hydroxyanthranilic acid dioxygenase, 4-dioxygenase, HAD

Gene ID: 23498

NCBI Accession: NP_036337

UniProt: P46952