IL16 antibody (N-Term)

Catalog No. ABIN499976

The Rabbit Polyclonal anti-IL16 antibody is suitable to detect IL16 in samples from Human, Mouse and Rat. It has been validated for WB and EIA.

Quick Overview for IL16 antibody (N-Term) (ABIN499976)

Target: IL16 (Interleukin 16 (IL16))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IL16 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Product Details anti-IL16 Antibody

Binding Specificity: N-Term

Specificity: This antibody reacts to IL-16.

Purification: Affinity chromatography purified via peptide column

Immunogen: IL-16 antibody was raised against a 14 amino acid peptide near the amino terminus of human IL-16.

Isotype: IgG

Application Details

Application Notes: ELISA. Western Blot: 1 - 2 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store the antibody undiluted at 2-8 °C.

Target Details for IL16

Target: IL16 (Interleukin 16 (IL16))

Alternative Name: Interleukin-16 / IL16

Background: IL-16 was initially identified as a chemotactic cytokine, but is now known to possess a wide range of activities. Later studies have more fully characterized IL-16 as an immunomodulatory cytokine that contributes to the regulatory process of CD4+ T cell recruitment and activation at sites of inflammation in association with asthma and several autoimmune diseases. The precursor of IL-16 (pro-IL-16) is thought to be cleaved towards the C-terminal region by Caspase-3, releasing a 20 kDa active form that binds to and signals through CD4. Besides acting as a chemotactic cytokine, IL-16 is thought to also be involved in the regulation of T cell proliferation and multiple infectious, immune-mediated, and autoimmune inflammatory disorders including irritable bowel syndrome, systemic lupus erythematosus, and neurodegenerative disorders. At least two isoforms of IL-16 are known to exist, the longer isoform (also known as NIL-16) is detected only in neurons of the cerebellum and hippocampus. This antibody will only detect the NIL-16 isoform.Synonyms: IL-16, LCF, Lymphocyte chemoattractant factor

Gene ID: 3603

NCBI Accession: NP_004504

UniProt: Q14005