IL21 Receptor antibody (Extracellular Domain)

Catalog No. ABIN499988

The Rabbit Polyclonal anti-IL21 Receptor antibody is suitable to detect IL21 Receptor in samples from Human, Mouse and Rat. It has been validated for WB, IHC (p) and EIA.

Quick Overview for IL21 Receptor antibody (Extracellular Domain) (ABIN499988)

Target: IL21 Receptor (IL21R) (Interleukin 21 Receptor (IL21R))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IL21 Receptor antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Product Details anti-IL21 Receptor Antibody

Binding Specificity: Extracellular Domain

Specificity: IL-21 receptor antibody was raised against a synthetic peptide corresponding to amino acids 97 to 111 of human IL-21 receptor precursor.

Purification: Affinity chromatography purified via peptide column

Immunogen: Human IL-21 Receptor (Extracellular Domain) Peptide

Isotype: IgG

Application Details

Application Notes: ELISA. Western Blot: 0.5 to 1 μg/mL. An approximately 60 kDa band can be detected. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Target Details for IL21 Receptor

Target: IL21 Receptor (IL21R) (Interleukin 21 Receptor (IL21R))

Alternative Name: Interleukin-21 Receptor / IL21R

Background: A novel cytokine related to IL-2 and IL-15 was recently identified and designated IL-21 . The receptor for IL-21 (IL-21R, also termed NILR for novel Interleukin receptor) is a new member of the class I cytokine receptor family (1,2). IL-21R forms a complex with the common cytokine receptor g chain, gc, and mediates IL-21 signaling (3,4). Both IL-21R and the gc are necessary for the IL-21 function. IL-21 and its receptor activate JAK-STAT signaling pathway. IL-21R is expressed in spleen, thymus, natural killer (NK), T and B cell lines. IL-21 plays a role in the proliferation and maturation of NK, B and T cell populations.Synonyms: IL-21R, IL21 receptor, NILR, Novel interleukin receptor

Gene ID: 50615

NCBI Accession: NP_068570

UniProt: Q9HBE5

Pathways: JAK-STAT Signaling