anti-IL22 Receptor alpha 1 antibody (Interleukin 22 Receptor, alpha 1) (N-Term)

Details for Product anti-IL22RA1 Antibody No. ABIN499994
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Synonyms IL22RA1, CRF2-9, IL22R, IL22R1, 9130219A07Rik, ENSMUSG00000073746, IL-22R, Il22r, RGD1559655
(18), (16), (7), (6), (4), (4), (3), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1)
Human, Rat (Rattus)
(74), (22), (21), (1), (1)
(62), (8), (4), (2)
This IL22 Receptor alpha 1 antibody is un-conjugated
(4), (4), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Enzyme Immunoassay (EIA), Immunofluorescence (IF), Western Blotting (WB)
(57), (27), (10), (8), (5), (4), (3), (3), (2), (1), (1), (1)
Pubmed 5 references available
Quantity 0.1 mg
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Availability Will be delivered in 6 to 8 Business Days
Immunogen Human IL-22 Receptor (N-Terminus) Peptide
Isotype IgG
Specificity IL-22 receptor antibody was raised against a synthetic peptide corresponding to amino acids near the amino terminus of human IL-22 receptor precursor.
Purification Affinity chromatography purified via peptide column
Alternative Name IL22RA1 / IL22R (IL22RA1 Antibody Abstract)
Background A novel cytokine, designated IL-TIF for IL-10 related T cell-derived inducible factor and IL-22, was recently identified (1-3). The receptor for IL-22 (IL-22R, also termed CRF2-9 and IL-TIF-R1 chain) is a new member of the class II cytokine receptor family (3,4). IL-22R forms a complex with IL-10 receptor b chain and mediates IL-22 signaling. IL-22 and its receptor activate JAK-STAT signaling pathway. IL22R is expressed in normal liver and kidney and their cell lines HepG2 and TK-10. A soluble form of IL-22 receptor, also termed IL-22 binding protein (IL-22BP) and IL-22 receptor-a 2 (IL-22RA2), was identified very recently (5-7). IL-22BP prevents binding of IL-22 to the functional cell surface IL-22R complex and neutralizes IL-22 activity. LPS induces IL-22 expression, which indicates the role of IL-22 in inflammatory response.Synonyms: CRF2-9, Cytokine receptor class-II member 9, Cytokine receptor family 2 member 9, IL-22 receptor subunit alpha-1, IL-22R-alpha-1, IL-22RA1, Interleukin-22 receptor subunit alpha-1, ZcytoR11
Gene ID 58985
UniProt Q8N6P7
Application Notes ELISA. Western Blot: 0.5 to 1 μg/mL. An approximately 62 kDa band can be detected. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Buffer PBS containing 0.02 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Supplier Images
Immunofluorescence (IF) image for anti-IL22 Receptor alpha 1 antibody (Interleukin 22 Receptor, alpha 1) (N-Term) (ABIN499994) Immunocytochemistry of IL-22 receptor in HepG2 cells with AP30417PU-N IL-22 receptor ...
Western Blotting (WB) image for anti-IL22 Receptor alpha 1 antibody (Interleukin 22 Receptor, alpha 1) (N-Term) (ABIN499994) Western blot analysis of IL-22 receptor expression in human HepG2 cell lysate with AP...
Background publications Pacchioni: "Two-dimensional oxides: multifunctional materials for advanced technologies." in: Chemistry (Weinheim an der Bergstrasse, Germany), Vol. 18, Issue 33, pp. 10144-58, 2012 (PubMed).

Kotenko, Izotova, Mirochnitchenko et al.: "Identification of the functional interleukin-22 (IL-22) receptor complex: the IL-10R2 chain (IL-10Rbeta ) is a common chain of both the IL-10 and IL-22 (IL-10-related T cell-derived inducible factor, ..." in: The Journal of biological chemistry, Vol. 276, Issue 4, pp. 2725-32, 2001 (PubMed).

Dumoutier, Van Roost, Colau et al.: "Human interleukin-10-related T cell-derived inducible factor: molecular cloning and functional characterization as an hepatocyte-stimulating factor." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, Issue 18, pp. 10144-9, 2000 (PubMed).

Xie, Aggarwal, Ho et al.: "Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22R." in: The Journal of biological chemistry, Vol. 275, Issue 40, pp. 31335-9, 2000 (PubMed).

Dumoutier, Louahed, Renauld: "Cloning and characterization of IL-10-related T cell-derived inducible factor (IL-TIF), a novel cytokine structurally related to IL-10 and inducible by IL-9." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 164, Issue 4, pp. 1814-9, 2000 (PubMed).

Catalog No. ABIN499994
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