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Interleukin 22 Receptor, alpha 1 (IL22RA1) (N-Term) antibody

Details for Product No. ABIN499994
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Antigen
Synonyms IL22R, CRF2-9, IL22R1, 9130219A07Rik, ENSMUSG00000073746, IL-22R, Il22r, RGD1559655, IL22RA1
Epitope
N-Term
(9), (9), (4), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Rat (Rattus)
(56), (24), (23), (18), (18), (17), (17)
Host
Rabbit
(52), (4), (3), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blotting (WB)
(38), (21), (14), (8), (6), (4), (3), (2), (1), (1)
Pubmed 5 references available
Quantity 0.1 mg
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
Catalog No. ABIN499994
401.50 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen Human IL-22 Receptor (N-Terminus) Peptide (AP30417CP-N)
Isotype IgG
Specificity IL-22 receptor antibody was raised against a synthetic peptide corresponding to amino acids near the amino terminus of human IL-22 receptor precursor.
Purification Affinity chromatography purified via peptide column
Alternative Name IL22RA1 / IL22R
Background A novel cytokine, designated IL-TIF for IL-10 related T cell-derived inducible factor and IL-22, was recently identified (1-3). The receptor for IL-22 (IL-22R, also termed CRF2-9 and IL-TIF-R1 chain) is a new member of the class II cytokine receptor family (3,4). IL-22R forms a complex with IL-10 receptor b chain and mediates IL-22 signaling. IL-22 and its receptor activate JAK-STAT signaling pathway. IL22R is expressed in normal liver and kidney and their cell lines HepG2 and TK-10. A soluble form of IL-22 receptor, also termed IL-22 binding protein (IL-22BP) and IL-22 receptor-a 2 (IL-22RA2), was identified very recently (5-7). IL-22BP prevents binding of IL-22 to the functional cell surface IL-22R complex and neutralizes IL-22 activity. LPS induces IL-22 expression, which indicates the role of IL-22 in inflammatory response.
Alternate names: CRF2-9, Cytokine receptor class-II member 9 Cytokine receptor family 2 member 9, IL-22 receptor subunit alpha-1, IL-22R-alpha-1, IL-22RA1, Interleukin-22 receptor subunit alpha-1, ZcytoR11
Gene ID 58985
NCBI Accession AF286095
UniProt Q8N6P7
Application Notes ELISA. Western Blot: 0.5 to 1 μg/ml. An approximately 62 kDa band can be detected. Immunocytochemistry. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer PBS containing 0.02% sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Expiry Date 12 months
Background publications Dumoutier, Louahed, Renauld: "Cloning and characterization of IL-10-related T cell-derived inducible factor (IL-TIF), a novel cytokine structurally related to IL-10 and inducible by IL-9." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 164, Issue 4, pp. 1814-9, 2000 (PubMed).

Xie, Aggarwal, Ho et al.: "Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22R." in: The Journal of biological chemistry, Vol. 275, Issue 40, pp. 31335-9, 2000 (PubMed).

Dumoutier, Van Roost, Colau et al.: "Human interleukin-10-related T cell-derived inducible factor: molecular cloning and functional characterization as an hepatocyte-stimulating factor." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, Issue 18, pp. 10144-9, 2000 (PubMed).

Kotenko, Izotova, Mirochnitchenko et al.: "Identification of the functional interleukin-22 (IL-22) receptor complex: the IL-10R2 chain (IL-10Rbeta ) is a common chain of both the IL-10 and IL-22 (IL-10-related T cell-derived inducible factor, IL-TIF) receptor complexes." in: The Journal of biological chemistry, Vol. 276, Issue 4, pp. 2725-32, 2001 (PubMed).

Pacchioni: "Two-dimensional oxides: multifunctional materials for advanced technologies." in: Chemistry (Weinheim an der Bergstrasse, Germany), Vol. 18, Issue 33, pp. 10144-58, 2012 (PubMed).

Hosts (52), (4), (3), (1)
Reactivities (56), (24), (23), (18), (18), (17), (17)
Applications (38), (21), (14), (8), (6), (4), (3), (2), (1), (1)
Conjugates (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (9), (9), (4), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN499994
401.50 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
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