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Interleukin 27 (IL27) (N-Term) antibody

Details for Product No. ABIN500000, Supplier: Log in to see
Antigen
  • IL27
  • IL-17D
  • IL-22
  • IL-27
  • IL-27A
  • IL27A
  • IL27p28
  • IL30
  • p28
  • IL-27p28
  • Il30
  • RGD1561420
Epitope
N-Term
23
17
14
13
11
10
7
6
5
5
4
3
3
3
2
2
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine)
82
62
10
1
1
Host
Rabbit
97
33
10
3
Clonality
Polyclonal
Conjugate
Un-conjugated
10
9
8
7
6
5
2
2
1
1
Application
Enzyme Immunoassay (EIA), Immunofluorescence (IF), Western Blotting (WB)
105
61
19
16
8
6
5
4
4
3
2
2
2
2
1
1
1
1
1
Supplier
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Immunogen Affinity chromatography purified via peptide column
Isotype IgG
Specificity This antibody reacts to IL-27.
Purification Affinity chromatography purified via peptide column
Alternative Name Interleukin-27 / IL27A (IL27 Antibody Abstract)
Background Like interleukin-23 (IL-23), IL-27 is a recently discovered member of the IL-6/IL-12 family of proinflammatory and immunoregulatory cytokines. It exists as a heterodimer composed of the p40-related protein EBI3 and an IL-12 p35-related protein termed p28. IL-27 is produced after activation by antigen-presenting cells and induces proliferation of naive but not memory CD4+ T-cells. It acts by binding to its receptor WSX-1 and gp130 which results in the activation of a Jak/STAT signaling cascade, suggesting the IL-27 is involved in the regulation of immune processes. It has been suggested that IL-27 can also be used as a therapeutic agent against cancer as it can also induce tumor-specific anti-tumor activity mediated through CD8+ T-cells, IFN-γ, and T-bet.Synonyms: IL-27 subunit alpha, IL-30, IL27-A, IL30, Interleukin-30, p28
Gene ID 246778
NCBI Accession NP_663634
UniProt Q8NEV9
Pathways
Application Notes ELISA. Western Blot: 2 - 4 μg/mL. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Buffer PBS containing 0.02 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Supplier Images
Immunofluorescence (IF) image for anti-Interleukin 27 (IL27) (N-Term) antibody (ABIN500000) Immunocytochemistry of IL-27 in EL4 with AP30420PU-N IL-27 antibody at 10 μg/ml.
Western Blotting (WB) image for anti-Interleukin 27 (IL27) (N-Term) antibody (ABIN500000) Western blot analysis of IL-27 in EL4 lysate with AP30420PU-N IL-27 antibody at (A) 2...
Background publications Hunter: "New IL-12-family members: IL-23 and IL-27, cytokines with divergent functions." in: Nature reviews. Immunology, Vol. 5, Issue 7, pp. 521-31, 2005 (PubMed).