Inhibitor of CDK, Cyclin A1 Interacting Protein 1 (INCA1) (C-Term) antibody

Details for Product No. ABIN500026
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Synonyms AI842396, RGD1306656
(6), (2), (2), (1)
Human, Mouse (Murine), Rat (Rattus)
(21), (19), (17), (11), (11)
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
ELISA, Western Blotting (WB)
(12), (9), (9), (3)
Pubmed 1 reference available
Catalog no. ABIN500026
Quantity 0.1 mg
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Immunogen INCA1 antibody was raised against a 15 amino acid peptide from near the carboxy terminus of human INCA1. (AP30433CP-N)
Isotype IgG
Purification Affinity chromatography purified via peptide column
Alternative Name INCA1 / HSD45
Background INCA1 was isolated through a yeast triple hybrid approach to identify interaction partners of the cyclin A1-CDK2 heterodimer. INCA1 is evolutionarily conserved and has no homology to any known proteins. Like Cyclin A1, INCA1 is highly expressed in testis with highest levels observed at various points of testis maturation. It has been suggested that the complex of INCA1 and the cyclinA1-CDK2 dimer plays a role in several signaling pathways important for cell cycle control and meiosis. Recent experiments have shown that INCA1 also interacts with the testis protein RSB-66 and this interaction takes place in the cytoplasm.
Alternate names: Inhibitor of CDK1 interacting with cyclin A1
Gene ID 388324
NCBI Accession NP_998891
UniProt Q0VD86
Application Notes ELISA. Western Blot: 1 - 2 μg/ml. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS containing 0.02% sodium azide.
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store the antibody (in aliquots) at -20°C.
Expiry Date 12 months
Background publications Diederichs, Bäumer, Ji et al.: "Identification of interaction partners and substrates of the cyclin A1-CDK2 complex." in: The Journal of biological chemistry, Vol. 279, Issue 32, pp. 33727-41, 2004 (PubMed).

Hosts (21)
Reactivities (21), (19), (17), (11), (11)
Applications (12), (9), (9), (3)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (6), (2), (2), (1)
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