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IRAK4 antibody

IRAK4 Reactivity: Human WB, IF, EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN500044
  • Target See all IRAK4 Antibodies
    IRAK4 (Interleukin-1 Receptor-Associated Kinase 4 (IRAK4))
    Reactivity
    • 102
    • 59
    • 20
    • 15
    • 14
    • 12
    • 3
    • 3
    • 2
    • 2
    • 1
    Human
    Host
    • 97
    • 11
    • 1
    Rabbit
    Clonality
    • 96
    • 13
    Polyclonal
    Conjugate
    • 51
    • 6
    • 5
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This IRAK4 antibody is un-conjugated
    Application
    • 102
    • 44
    • 37
    • 26
    • 18
    • 15
    • 13
    • 8
    • 8
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)
    Specificity
    IRAK-4 antibody was raised against a synthetic peptide corresponding to amino acids at the carboxy terminus of human IRAK-4. Anti-IRAK-4 has no cross response to other IRAKs.
    Purification
    Affinity chromatography purified via peptide column
    Immunogen
    Human IRAK4 Peptide
    Isotype
    IgG
    Top Product
    Discover our top product IRAK4 Primary Antibody
  • Application Notes
    ELISA. Western Blot: 1 to 2 μg/mL. A 50 kDa band can be detected. Immunocytochemistry.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Buffer
    PBS containing 0.02 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C.
  • Target
    IRAK4 (Interleukin-1 Receptor-Associated Kinase 4 (IRAK4))
    Alternative Name
    IRAK4 (IRAK4 Products)
    Background
    Interleukin-1 (IL-1) and lipopolysaccharide (LPS) induces cellular responses through IL-1 receptor (IL-1R) and Toll-like receptors (TLR). IL-1R-associated kinases (IRAK, IRAK2, and IRAK-M) regulate the activation of NF-kappaB and MAP kinase (MAPK) by IL-1R/TLR (1-3). A novel member in the IRAK/Pelle family was recently identified and designated IRAK-4 (4,5). Overexpression of IRAK-4 activates NF-kB and MAPK pathways. IRAK-4 interacts with and phosphorylates IRAK-1. IRAK-4-deficient animals are completely resistant to the challenge with LPS. Animals and humans lacking IRAK-4 are impaired in their responses to viral and bacterial challenges (5,6). Members in IRAK/Pelle family play a central role in IL-1R/TLR mediated inflammatory responses and in innate immunity.Synonyms: IRAK-4, Interleukin-1 receptor-associated kinase-like, NY-REN-64
    Gene ID
    51135
    UniProt
    Q9NWZ3
    Pathways
    NF-kappaB Signaling, TLR Signaling, Activation of Innate immune Response, Toll-Like Receptors Cascades
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