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Details for Product No. ABIN500044

Interleukin-1 Receptor-Associated Kinase 4 (IRAK4) antibody

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Antigen
Synonyms IPD1, IRAK-4, NY-REN-64, REN64, 8430405M07Rik, 9330209D03Rik, zgc:55553, IRAK4, ipd1, irak-4, ny-ran-64, ny-ren-64, ren64, irak4
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blotting (WB)
Pubmed 2 references available
Catalog no. ABIN500044
Quantity 0.1 mg
Price
390.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 8 Business Days

Product details

Target Details Application Details Handling References Alternatives back to top
Immunogen Human IRAK4 Peptide (AP30442CP-N)
Isotype IgG
Specificity IRAK-4 antibody was raised against a synthetic peptide corresponding to amino acids at the carboxy terminus of human IRAK-4. Anti-IRAK-4 has no cross response to other IRAKs.
Purification Affinity chromatography purified via peptide column

Target Details

Application Details Handling References Alternatives back to top
Alternative Name IRAK4
Background Interleukin-1 (IL-1) and lipopolysaccharide (LPS) induces cellular responses through IL-1 receptor (IL-1R) and Toll-like receptors (TLR). IL-1R-associated kinases (IRAK, IRAK2, and IRAK-M) regulate the activation of NF-kappaB and MAP kinase (MAPK) by IL-1R/TLR (1-3). A novel member in the IRAK/Pelle family was recently identified and designated IRAK-4 (4,5). Overexpression of IRAK-4 activates NF-kB and MAPK pathways. IRAK-4 interacts with and phosphorylates IRAK-1. IRAK-4-deficient animals are completely resistant to the challenge with LPS. Animals and humans lacking IRAK-4 are impaired in their responses to viral and bacterial challenges (5,6). Members in IRAK/Pelle family play a central role in IL-1R/TLR mediated inflammatory responses and in innate immunity.
Alternate names: IRAK-4, Interleukin-1 receptor-associated kinase-like, NY-REN-64
Gene ID 51135
NCBI Accession AAM15772
UniProt Q9NWZ3
Research Area Immunology, Innate Immunity, Atherosclerosis, Cytokines, Receptors, Inflammation

Application Details

Target Details Handling References Alternatives back to top
Application Notes ELISA. Western Blot: 1 to 2 μg/ml. A 50 kDa band can be detected. Immunocytochemistry. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only

Handling

Target Details Application Details References Alternatives back to top
Format Liquid
Buffer PBS containing 0.02% sodium azide.
Preservative Sodium azide
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8°C.
Expiry Date 12 months

References

Target Details Application Details Handling Alternatives back to top
Background publications Cao, Henzel, Gao: "IRAK: a kinase associated with the interleukin-1 receptor." in: Science (New York, N.Y.), Vol. 271, Issue 5252, pp. 1128-31, 1996 (PubMed).

Muzio, Ni, Feng et al.: "IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling." in: Science (New York, N.Y.), Vol. 278, Issue 5343, pp. 1612-5, 1997 (PubMed).

Alternatives

Target Details Application Details Handling References back to top
Alternatives for antigen "Interleukin-1 Receptor-Associated Kinase 4 (IRAK4)", type "Antibodies"
Hosts (73), (30), (11)
Reactivities (111), (40), (25), (24), (24), (24), (6), (1)
Applications (81), (42), (23), (20), (13), (8), (5), (4), (2), (2), (2), (1)
Conjugates (6), (4), (4), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Epitopes (21), (17), (13), (5), (4), (3), (2), (2), (2), (2), (2), (1), (1)
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