Interleukin-1 Receptor-Associated Kinase 4 (IRAK4) antibody

Details for Product No. ABIN500044
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Antigen
Synonyms zgc:55553, IRAK4, ipd1, irak-4, ny-ran-64, ny-ren-64, ren64, irak4, IPD1, IRAK-4, NY-REN-64, REN64, 8430405M07Rik, 9330209D03Rik
Reactivity
Human
(98), (34), (13), (12), (12), (12), (7), (1)
Host
Rabbit
(70), (28), (10)
Clonality
Polyclonal
Conjugate
Un-conjugated
(5), (3), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Application
Enzyme Immunoassay (EIA), Immunofluorescence (IF), Western Blotting (WB)
(87), (43), (22), (10), (10), (6), (5), (5), (5), (5), (3), (3), (1), (1), (1)
Pubmed 2 references available
Quantity 0.1 mg
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
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Catalog No. ABIN500044
401.50 $
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Immunogen Human IRAK4 Peptide
Isotype IgG
Specificity IRAK-4 antibody was raised against a synthetic peptide corresponding to amino acids at the carboxy terminus of human IRAK-4. Anti-IRAK-4 has no cross response to other IRAKs.
Purification Affinity chromatography purified via peptide column
Alternative Name IRAK4
Background Interleukin-1 (IL-1) and lipopolysaccharide (LPS) induces cellular responses through IL-1 receptor (IL-1R) and Toll-like receptors (TLR). IL-1R-associated kinases (IRAK, IRAK2, and IRAK-M) regulate the activation of NF-kappaB and MAP kinase (MAPK) by IL-1R/TLR (1-3). A novel member in the IRAK/Pelle family was recently identified and designated IRAK-4 (4,5). Overexpression of IRAK-4 activates NF-kB and MAPK pathways. IRAK-4 interacts with and phosphorylates IRAK-1. IRAK-4-deficient animals are completely resistant to the challenge with LPS. Animals and humans lacking IRAK-4 are impaired in their responses to viral and bacterial challenges (5,6). Members in IRAK/Pelle family play a central role in IL-1R/TLR mediated inflammatory responses and in innate immunity.Synonyms: IRAK-4, Interleukin-1 receptor-associated kinase-like, NY-REN-64
Gene ID 51135
UniProt Q9NWZ3
Research Area Immunology, Innate Immunity, Atherosclerosis, Cytokines, Receptors, Inflammation
Application Notes ELISA. Western Blot: 1 to 2 μg/mL. A 50 kDa band can be detected. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Buffer PBS containing 0.02 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8 °C.
Background publications Muzio, Ni, Feng et al.: "IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling." in: Science (New York, N.Y.), Vol. 278, Issue 5343, pp. 1612-5, 1997 (PubMed).

Cao, Henzel, Gao: "IRAK: a kinase associated with the interleukin-1 receptor." in: Science (New York, N.Y.), Vol. 271, Issue 5252, pp. 1128-31, 1996 (PubMed).

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