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Details for Product No. ABIN500044

Interleukin-1 Receptor-Associated Kinase 4 (IRAK4) antibody

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Antigen
Synonyms	IPD1, IRAK-4, NY-REN-64, REN64, 8430405M07Rik, 9330209D03Rik, zgc:55553, IRAK4, ipd1, irak-4, ny-ran-64, ny-ren-64, ren64, irak4
Reactivity	Alternatives Human (106), (39), (25), (24), (24), (24), (5), (1)
Host	Alternatives Rabbit (69), (29), (11)
Clonality	Polyclonal
Conjugate	Alternatives Un-conjugated (6), (4), (4), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Application	Alternatives ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blotting (WB) (76), (41), (23), (20), (13), (8), (5), (3), (2), (2), (1), (1)
	2 references available

Catalog no.	ABIN500044
Quantity	0.1 mg
Price	390.50 $ Plus shipping costs $45.00

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Product details

Alternative Name	IRAK4
Background	Interleukin-1 (IL-1) and lipopolysaccharide (LPS) induces cellular responses through IL-1 receptor (IL-1R) and Toll-like receptors (TLR). IL-1R-associated kinases (IRAK, IRAK2, and IRAK-M) regulate the activation of NF-kappaB and MAP kinase (MAPK) by IL-1R/TLR (1-3). A novel member in the IRAK/Pelle family was recently identified and designated IRAK-4 (4,5). Overexpression of IRAK-4 activates NF-kB and MAPK pathways. IRAK-4 interacts with and phosphorylates IRAK-1. IRAK-4-deficient animals are completely resistant to the challenge with LPS. Animals and humans lacking IRAK-4 are impaired in their responses to viral and bacterial challenges (5,6). Members in IRAK/Pelle family play a central role in IL-1R/TLR mediated inflammatory responses and in innate immunity. Alternate names: IRAK-4, Interleukin-1 receptor-associated kinase-like, NY-REN-64
Gene ID	51135
NCBI Accession	AAM15772
UniProt	Q9NWZ3
Research Area	Immunology, Innate Immunity, Atherosclerosis, Cytokines, Receptors, Inflammation

Alternatives for antigen "Interleukin-1 Receptor-Associated Kinase 4 (IRAK4)", type "Antibodies"

Immunogen	Human IRAK4 Peptide (AP30442CP-N)
Isotype	IgG
Specificity	IRAK-4 antibody was raised against a synthetic peptide corresponding to amino acids at the carboxy terminus of human IRAK-4. Anti-IRAK-4 has no cross response to other IRAKs.
Purification	Affinity chromatography purified via peptide column

Application Notes	ELISA. Western Blot: 1 to 2 μg/ml. A 50 kDa band can be detected. Immunocytochemistry. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions	For Research Use only

Format	Liquid
Buffer	PBS containing 0.02% sodium azide.
Preservative	Sodium azide
Storage	4 °C
Storage Comment	Store the antibody undiluted at 2-8°C.
Expiry Date	12 months

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