SEC16B antibody (C-Term)

Catalog No. ABIN500212

This Rabbit Polyclonal antibody specifically detects SEC16B in WB, IHC (p) and EIA. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for SEC16B antibody (C-Term) (ABIN500212)

Target: SEC16B (SEC16 Homolog B (SEC16B))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SEC16B antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Product Details anti-SEC16B Antibody

Binding Specificity: C-Term

Cross-Reactivity (Details): Species reactivity (tested):Humna, Mouse, Rat

Purification: Peptide affinity chromatography

Immunogen: LZTR2 antibody was raised against an 18 amino acid peptide near the carboxy terminus of human LZTR2.

Isotype: IgG

Application Details

Application Notes: ELISA. Western blot: 1 - 2 μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store the antibody (in aliquots) at -20 °C.

Target Details for SEC16B

Target: SEC16B (SEC16 Homolog B (SEC16B))

Alternative Name: SEC16B

Background: LZTR2, also known as RGPR-p117, is a member of the BTB-kelch superfamily and was initially described as a nuclear factor I (NFI) binding protein and transcriptional regulator of the regucalcin gene. LZTR2 is cytoplasmically localized but is thought to translocate to the nucleus, a process mediated by protein kinase C signaling following hormonal stimulation. Recent evidence has suggested that there is a strong correlation of single nucleotide polymorphisms of LZTR2 with obesity in the Japanese population similar to that seen with the TMEM18 gene and the GNPDA2, BDNF, FAIM2, and MC4R genes with obesity in Caucasian populations, suggesting LZTR2 may play a role in metabolism and obesity risk.Synonyms: KIAA1928, LZTR2, Leucine zipper transcription regulator 2, Protein SEC16 homolog B, Protein transport protein Sec16B, RGPR, RGPR-p117, Regucalcin gene promoter region-related protein p117, SEC16B, SEC16S

Gene ID: 89866

NCBI Accession: NP_149118

UniProt: Q96JE7