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TP53AIP1 antibody (N-Term)

TP53AIP1 Reactivity: Human WB, IF, EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN500433
  • Target See all TP53AIP1 Antibodies
    TP53AIP1 (P53-Regulated Apoptosis-Inducing Protein 1 (TP53AIP1))
    Binding Specificity
    • 15
    • 3
    • 2
    • 1
    • 1
    • 1
    N-Term
    Reactivity
    • 25
    • 17
    • 2
    Human
    Host
    • 25
    • 1
    Rabbit
    Clonality
    • 26
    Polyclonal
    Conjugate
    • 12
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This TP53AIP1 antibody is un-conjugated
    Application
    • 20
    • 13
    • 13
    • 11
    • 5
    • 4
    • 4
    • 3
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)
    Specificity
    This antibody dreacts to p53AIP1. It will detect all three isoforms.
    Cross-Reactivity (Details)
    Species reactivity (tested):Human
    Purification
    Peptide affinity chromatograpy
    Immunogen
    p53AIP1 antibody was raised against a 15 amino acid peptide from near the amino terminus of human p53AIP1.
    Isotype
    IgG
    Top Product
    Discover our top product TP53AIP1 Primary Antibody
  • Application Notes
    ELISA. Western blot: 4 - 8 μg/mL. Immunocytochemistry.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Buffer
    PBS containing 0.02 % sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
  • Ohno, Naito, Mukai, Yabuta, Nojima: "ELAS1-mediated inhibition of the cyclin G1-B'γ interaction promotes cancer cell apoptosis via stabilization and activation of p53." in: Oncogene, Vol. 34, Issue 49, pp. 5983-96, (2016) (PubMed).

  • Target
    TP53AIP1 (P53-Regulated Apoptosis-Inducing Protein 1 (TP53AIP1))
    Alternative Name
    TP53AIP1 (TP53AIP1 Products)
    Synonyms
    P53AIP1 antibody, tumor protein p53 regulated apoptosis inducing protein 1 antibody, TP53AIP1 antibody
    Background
    The p53 tumor-suppressor protein can induce apoptosis through transcriptional activation of several genes. One such protein p53AIP was initially identified through direct cloning of p53 binding sequences from human genomic DNA. Its expression is inducible by p53 following p53 phosphorylation on Ser-46, and ectopic expression of p53AIP leads to apoptotic cell death. Both the phosphorylation of p53 and the induction of p53AIP were blocked by inhibiting the expression of p53DINP1 by the introduction of antisense oligonucleotides to p53DINP1, suggesting that the apoptosis associated with p53AIP expression is regulated by p53DINP1. Finally, as adenovirus-mediated introduction of p53AIP has been shown to suppress tumor growth in vivo, it has been suggested that p53AIP gene transfer may become a useful strategy for the treatment of p53-resistant cancers. Three isoforms of p53AIP are known to existSynonyms: p53-regulated apoptosis-inducing protein 1, p53AIP1
    Gene ID
    63970
    UniProt
    Q9HCN2
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