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RIPK2 antibody (Receptor-Interacting Serine-threonine Kinase 2) (AA 508-522)

Details for Product anti-RIPK2 Antibody No. ABIN500601, Supplier: Log in to see
Antigen
  • RIPK2
  • 2210420D18Rik
  • CARD3
  • CARDIAK
  • CCK
  • D4Bwg0615e
  • RICK
  • RIP2
  • GIG30
Alternatives
anti-Human RIPK2 antibody for Western Blotting
Epitope
AA 508-522, C-Term
30
18
9
8
5
5
4
4
3
3
3
3
2
2
2
2
2
1
1
1
1
Reactivity
Human
136
36
22
4
4
2
2
2
Host
Rabbit
116
16
4
Clonality
Polyclonal
Conjugate
This RIPK2 antibody is un-conjugated
6
5
4
2
2
2
Application
Enzyme Immunoassay (EIA), Immunofluorescence (IF), Western Blotting (WB)
123
70
40
18
13
12
3
3
2
2
1
Supplier
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Immunogen RICK antibody was raised against a peptide corresponding to amino acids 508 to 522 of human origin.
Isotype IgG
Specificity This antibody detects RICK at C-term.
Cross-Reactivity (Details) Species reactivity (tested):Human
Purification Peptide affinity chromatography
Alternative Name RIPK2 (RIPK2 Antibody Abstract)
Background Apoptosis is mediated by death domain (DD) and/or caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. DD-containing serine/threonine kinase RIP regulates Fas-induced apoptosis. A novel CARD-containing serine/threonine kinase was recently identified and designated RICK/RIP2/CARDIAK for RIP-like interacting CLARP kinase, receptor interacting protein-2, and CARD-containing ICE associated kinase, respectively, (1-3). RICK contains an N-terminal kinase catalytic domain and a C-terminal CARD domain. Overexpression of RICK induced apoptosis and activation of NF-kappaB and JNK. RICK interacts with members of the TRAF family, CLARP and caspase-1. Thus, RICK represents a novel kinase that regulates TNF and Fas induced-apoptosis and that is involved in the generation of proinflammatory cytokine IL-1b. The messenger RNA of RICK is expressed in multiple human tissues (1).Synonyms: CARD-containing IL-1 beta ICE-kinase, CARDIAK, RICK, RIP-2, RIP-like-interacting CLARP kinase, RIP2, Receptor-interacting protein 2, Receptor-interacting serine/threonine-protein kinase 2
Gene ID 8767
UniProt O43353
Research Area Apoptosis/Necrosis, Signaling
Pathways TCR Signaling, Neurotrophin Signaling Pathway
Application Notes ELISA. Western blot: 1: 500, an approximately 60 kDa band can be detected. Immunoflourescence.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Buffer PBS containing 0.02 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
Supplier Images
Immunofluorescence (IF) image for anti-RIPK2 antibody (Receptor-Interacting Serine-threonine Kinase 2) (AA 508-522) (ABIN500601) Immunocytochemistry of RICK in K562 cells with this product at 5 μg/ml.
Background publications Thome, Hofmann, Burns et al.: "Identification of CARDIAK, a RIP-like kinase that associates with caspase-1." in: Current biology : CB, Vol. 8, Issue 15, pp. 885-8, 1998 (PubMed).

McCarthy, Ni, Dixit: "RIP2 is a novel NF-kappaB-activating and cell death-inducing kinase." in: The Journal of biological chemistry, Vol. 273, Issue 27, pp. 16968-75, 1998 (PubMed).

Inohara, del Peso, Koseki et al.: "RICK, a novel protein kinase containing a caspase recruitment domain, interacts with CLARP and regulates CD95-mediated apoptosis." in: The Journal of biological chemistry, Vol. 273, Issue 20, pp. 12296-300, 1998 (PubMed).