Receptor-Interacting Serine-threonine Kinase 2 (RIPK2) (AA 508-522), (C-Term) antibody

Details for Product No. ABIN500601
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Antigen
Synonyms 2210420D18Rik, CARD3, CARDIAK, CCK, D4Bwg0615e, RICK, RIP2, GIG30, RIPK2
Epitope
AA 508-522, C-Term
(13), (13), (13), (5), (4), (3), (2), (2), (1), (1), (1), (1)
Reactivity
Human
(100), (42), (22), (1), (1), (1)
Host
Rabbit
(82), (14), (5)
Clonality
Polyclonal
Application
ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blotting (WB)
(97), (50), (28), (23), (10), (6), (3), (2), (1), (1), (1)
Pubmed 3 references available
Catalog no. ABIN500601
Quantity 0.1 mg
Price
401.50 $   Plus shipping costs $45.00
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Immunogen RICK antibody was raised against a peptide corresponding to amino acids 508 to 522 of human origin.
Isotype IgG
Specificity This antibody detects RICK at C-term. Species Reactivity: Tested: Human
Purification Peptide affinity chromatography
Alternative Name RIPK2
Background Apoptosis is mediated by death domain (DD) and/or caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. DD-containing serine/threonine kinase RIP regulates Fas-induced apoptosis. A novel CARD-containing serine/threonine kinase was recently identified and designated RICK/RIP2/CARDIAK for RIP-like interacting CLARP kinase, receptor interacting protein-2, and CARD-containing ICE associated kinase, respectively, (1-3). RICK contains an N-terminal kinase catalytic domain and a C-terminal CARD domain. Overexpression of RICK induced apoptosis and activation of NF-kappaB and JNK. RICK interacts with members of the TRAF family, CLARP and caspase-1. Thus, RICK represents a novel kinase that regulates TNF and Fas induced-apoptosis and that is involved in the generation of proinflammatory cytokine IL-1b. The messenger RNA of RICK is expressed in multiple human tissues (1).
Alternate names: CARD-containing IL-1 beta ICE-kinase, CARDIAK, RICK, RIP-2, RIP-like-interacting CLARP kinase, RIP2, Receptor-interacting protein 2, Receptor-interacting serine/threonine-protein kinase 2
Gene ID 8767
NCBI Accession AF027706
UniProt O43353
Research Area Apoptosis/Necrosis, Signaling
Application Notes ELISA. Western blot: 1: 500, an approximately 60 kDa band can be detected. Immunoflourescence. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer PBS containing 0.02% sodium azide
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
Expiry Date 12 months
Background publications Inohara, del Peso, Koseki et al.: "RICK, a novel protein kinase containing a caspase recruitment domain, interacts with CLARP and regulates CD95-mediated apoptosis." in: The Journal of biological chemistry, Vol. 273, Issue 20, pp. 12296-300, 1998 (PubMed).

McCarthy, Ni, Dixit: "RIP2 is a novel NF-kappaB-activating and cell death-inducing kinase." in: The Journal of biological chemistry, Vol. 273, Issue 27, pp. 16968-75, 1998 (PubMed).

Thome, Hofmann, Burns et al.: "Identification of CARDIAK, a RIP-like kinase that associates with caspase-1." in: Current biology : CB, Vol. 8, Issue 15, pp. 885-8, 1998 (PubMed).

Hosts (82), (14), (5)
Reactivities (100), (42), (22), (1), (1), (1)
Applications (97), (50), (28), (23), (10), (6), (3), (2), (1), (1), (1)
Epitopes (13), (13), (13), (5), (4), (3), (2), (2), (1), (1), (1), (1)
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