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SLIT and NTRK-Like Family, Member 1 (SLITRK1) (C-Term) antibody

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Synonyms DKFZp459G0529, LRRC12, TTM, 3200001I04Rik
(23), (7), (5), (3), (2), (2), (1), (1), (1), (1), (1)
Human, Mouse (Murine), Rat (Rattus)
(58), (34), (32), (3), (3), (2), (1), (1)
(46), (15)
(3), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(34), (32), (17), (11), (8), (2), (1), (1)
Pubmed 4 references available
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Quantity 0.1 mg
Shipping to United States ( )
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Immunogen Slitrk1 antibody was raised against a 16 amino acid peptide from near the carboxy terminus of human Slitrk1.
Isotype IgG
Specificity This antibody detects SLITRK1 at C-term. It is predicted to have no cross-reactivity to other Slitrk proteins.
Cross-Reactivity (Details) Species reactivity (tested):Huamn, mouse, rat
Purification Peptide affinity chromatography
Alternative Name SLITRK1 (SLITRK1 Antibody Abstract)
Background SLIT and NTRK-like family 1 (Slitrk1) is a member a protein family consisting of six homologous transmembrane proteins (Slitrk1-6) that share two conserved leucine-rich repeat domains in the extracellular domain and have significant homology to Slit, a secreted axonal growth-controlling protein. These proteins are also homologous to trk neurotrophin receptors in their intracellular domains. Expression of Slitrk proteins is highly restricted to neural and brain tumor tissues, but varies within the family. For example, Slitrk1 is expressed primarily in mature neurons. Overexpression of Slitrk1 in transfected neuronal cells induced unipolar neurites, while expression of the other Slitrk proteins inhibited neurite outgrowth, suggesting that these proteins are involved in the control of neurite outgrowth. While Slitrk1 variants have been suggested associated with Tourette's Syndrome, it is thought to play only a minor role if at all.Synonyms: KIAA1910, LRRC12, Leucine-rich repeat-containing protein 12, SLIT and NTRK-like protein 1
Gene ID 114798
NCBI Accession NP_443142
UniProt Q96PX8
Application Notes ELISA. Western blot: 1 - 2 μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Buffer PBS containing 0.02 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
Supplier Images
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-SLIT and NTRK-Like Family, Member 1 (SLITRK1) (C-Term) antibody (ABIN500750) Immunohistochemistry of Slitrk1 in human brain tissue with this product at 2.5 μg/ml.
Western Blotting (WB) image for anti-SLIT and NTRK-Like Family, Member 1 (SLITRK1) (C-Term) antibody (ABIN500750) Western blot analysis of Slitrk1 in human brain tissue lysate with this product at (A...
Background publications Fabbrini, Pasquini, Aurilia et al.: "A large Italian family with Gilles de la Tourette syndrome: clinical study and analysis of the SLITRK1 gene." in: Movement disorders : official journal of the Movement Disorder Society, Vol. 22, Issue 15, pp. 2229-34, 2007 (PubMed).

Abelson, Kwan, ORoak et al.: "Sequence variants in SLITRK1 are associated with Tourette's syndrome." in: Science (New York, N.Y.), Vol. 310, Issue 5746, pp. 317-20, 2005 (PubMed).

Aruga, Yokota, Mikoshiba: "Human SLITRK family genes: genomic organization and expression profiling in normal brain and brain tumor tissue." in: Gene, Vol. 315, pp. 87-94, 2003 (PubMed).

Aruga, Mikoshiba: "Identification and characterization of Slitrk, a novel neuronal transmembrane protein family controlling neurite outgrowth." in: Molecular and cellular neurosciences, Vol. 24, Issue 1, pp. 117-29, 2003 (PubMed).

Catalog No. ABIN500750
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