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Details for Product No. ABIN500815

Signal Transducer and Activator of Transcription 1, 91kDa (STAT1) (C-Term) antibody

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Synonyms CANDF7, ISGF-3, STAT91, AA408197, 2010005J02Rik, DD6G4-4, XStat1, STAT4, IMUP, H2RSP, IMUP-1, IMUP-2
»Alternatives C-Term
»Alternatives Human, Mouse (Murine), Rat (Rattus)
»Alternatives Rabbit
Clonality Polyclonal
»Alternatives Un-conjugated
»Alternatives ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF), Immunoprecipitation (IP), Western Blotting (WB)
Pubmed 4 references available
Catalog no. ABIN500815
Quantity 0.1 mg
390.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 8 Business Days
Immunogen STAT1 antibody was raised against a peptide corresponding to amino acids near the carboxy terminus of human STAT1 alpha. Remarks: The sequences differ from the murine corresponding sequences by four amino acids.
Isotype IgG
Specificity This antibody detects STAT1 alpha (C-term) at a 91 kDa band. No reaction to the 84 kDa STAT1a.
Purification DEAE purified
Alternative Name STAT1
Background STATs (signal transducers and activators of transcription) are a family of cytoplasmic latent transcription factors that are activated to regulate gene expression in response to a large number of extracellular signaling polypeptides including cytokines, interferons, and growth factors. After phosphorylation by JAK tyrosine kinases, STATs enter the nucleus to regulate transcription of many different genes. Among the seven STATs (Stat1, Stat2, Stat3, Stat4, Stat5a, Stat5b, and Stat6), Stat1, Stat3, Stat5alpha, and Stat5beta have a wide activation profile. STAT1 is activated by many different ligands including IFN family (IFN-alpha, IFN- beta, IFN-gamma and IL-10), gp130 family (IL-6, IL-11, LIF, CNTF, and G-CSF), and receptor tyrosine kinases (EGF, PDGF, and CSF-1). STAT1 has two forms, the 91 kDa STAT1alpha and the 84 kDa STAT1beta which are encoded by the same gene with splicing variant.
Alternate names: Signal transducer and activator of transcription 1-alpha/beta, Transcription factor ISGF-3 components p91/p84
Gene ID 6772
NCBI Accession NP_009330
Research Area Cancer, Transcription Factors, Signaling, Receptors, Inflammation
Application Notes ELISA. Western blot: 1: 1000 - 1: 2000. Immunoprecipitation: 2 - 4 µg. Immunoflourescence. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer PBS containing 0.02% sodium azide
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
Expiry Date 12 months
Background publications Schindler, Fu, Improta et al.: "Proteins of transcription factor ISGF-3: one gene encodes the 91-and 84-kDa ISGF-3 proteins that are activated by interferon alpha." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 89, Issue 16, pp. 7836-9, 1992 (PubMed).

Schindler, Darnell: "Transcriptional responses to polypeptide ligands: the JAK-STAT pathway." in: Annual review of biochemistry, Vol. 64, pp. 621-51, 1995 (PubMed).

Darnell: "STATs and gene regulation." in: Science (New York, N.Y.), Vol. 277, Issue 5332, pp. 1630-5, 1997 (PubMed).

Leonard, OShea: "Jaks and STATs: biological implications." in: Annual review of immunology, Vol. 16, pp. 293-322, 1998 (PubMed).

Alternatives for antigen "Signal Transducer and Activator of Transcription 1, 91kDa (STAT1)", type "Antibodies"
Hosts (228), (65), (5), (5), (2)
Reactivities (284), (157), (140), (44), (41), (30), (27), (3), (2), (1)
Applications (262), (87), (78), (75), (68), (30), (25), (15), (6), (6), (4), (3), (3), (1), (1), (1)
Conjugates (4), (4), (3), (3), (3), (3), (3), (3), (3), (3), (3), (1), (1)
Epitopes (51), (47), (36), (8), (4), (4), (4), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)