STAT1 antibody (C-Term)

Catalog No. ABIN1881847

This Rabbit Polyclonal antibody specifically detects STAT1 in WB, IF, IHC (p) and FACS. It exhibits reactivity toward Human. It has been mentioned in 4+ publications

Quick Overview for STAT1 antibody (C-Term) (ABIN1881847)

Target: STAT1 (Signal Transducer and Activator of Transcription 1, 91kDa (STAT1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This STAT1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Clone: RB41406

Product Details anti-STAT1 Antibody

Binding Specificity: AA 717-745, C-Term

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This STAT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 717-745 amino acids from the C-terminal region of human STAT1.

Isotype: Ig Fraction

Application Details

Application Notes: IF: 1:25. WB: 1:1000. IHC-P-Leica: 1:1000. IHC-P-Leica: 1:500. IHC-P-Leica: 1:500. FC: 1:25

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-STAT1 antibody (ABIN1881847)

Yang, Shen, Xu, Yang, Tsai, Keng, Chen, Lee: "Enhancing NK cell-mediated cytotoxicity to cisplatin-resistant lung cancer cells via MEK/Erk signaling inhibition." in: Scientific reports, Vol. 7, Issue 1, pp. 7958, (2017) (PubMed).

Clarke, Clifford, Jindarat, Proud, Pang, Belvisi, Knox: "TNFα and IFNγ synergistically enhance transcriptional activation of CXCL10 in human airway smooth muscle cells via STAT-1, NF-κB, and the transcriptional coactivator CREB-binding protein." in: The Journal of biological chemistry, Vol. 285, Issue 38, pp. 29101-10, (2010) (PubMed).

Sakamoto, Qin, Navarro, Gamero, Potla, Yi, Zhu, Baker, Feldman, Larner: "Cells previously desensitized to type 1 interferons display different mechanisms of activation of stat-dependent gene expression from naïve cells." in: The Journal of biological chemistry, Vol. 279, Issue 5, pp. 3245-53, (2004) (PubMed).

Zhang, Cho, Petersen, Zhu, Dong: "Evidence of STAT1 phosphorylation modulated by MAPKs, MEK1 and MSK1." in: Carcinogenesis, Vol. 25, Issue 7, pp. 1165-75, (2004) (PubMed).

Target Details for STAT1

Target: STAT1 (Signal Transducer and Activator of Transcription 1, 91kDa (STAT1))

Alternative Name: STAT1

Background: The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. Two alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq].

Molecular Weight: 87335

NCBI Accession: NP_009330, NP_644671

UniProt: P42224

Pathways: JAK-STAT Signaling, RTK Signaling, Interferon-gamma Pathway, Response to Growth Hormone Stimulus, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Endopeptidase Activity, Hepatitis C, CXCR4-mediated Signaling Events