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Thioesterase Superfamily Member 4 (THEM4) (Center) antibody

Details for Product No. ABIN500905
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Antigen
Synonyms CTMP, 2700077M13Rik, 4921507I02Rik, RGD1304723, them4, THEM4
Epitope
Center
(4), (2), (2), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(16), (11), (11)
Host
Rabbit
(13), (2)
Clonality
Polyclonal
Application
ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(15), (12), (10), (3), (3), (2), (1)
Pubmed 3 references available
Quantity 0.1 mg
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
Catalog No. ABIN500905
401.50 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen THEM4 antibody was raised against an 18 amino acid peptide near the center of human THEM4.
Isotype IgG
Specificity This antibody detects THEM4 / CTMP.
Purification Peptide affinity chropmatography
Alternative Name THEM4 / CTMP
Background THEM4, also known as CTMP, binds specifically to the carboxy-terminal regulatory domain of PKB/Akt at the plasma membrane and acts as a negative regulator, reversing the phenotype of v-Akt-transformed cells. Hypermethylation of the THEM4 promoter and transcriptional downregulation of the gene has been reported in multiple glioblastomas, suggesting that epigenetic regulation of THEM4 may play a role in the progression of this cancer. Bioinformatic analysis, confirmed by in vitro testing, indicates that THEM4 is a broad-range, high activity acyl-CoA thioesterase. Recent reports have also indicated that TMEM4 is a mitochondrial protein whose overexpression is associated with an increase in mitochondrial membrane depolarization and caspase-3 and PARP cleavage, suggesting that THEM4 is involved in the apoptotic program. The additional higher molecular weight bands seen in the immunoblot may represent post-translationally modified TMEM4.
Alternate names: Carboxyl-terminal modulator protein, Thioesterase superfamily member 4
Gene ID 117145
NCBI Accession NP_444283
Application Notes ELISA. Western blot: 1 - 2 μg/ml. Immunohistochemistry on paraffin sections. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer PBS containing 0.02% sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
Expiry Date 12 months
Background publications Maira, Galetic, Brazil et al.: "Carboxyl-terminal modulator protein (CTMP), a negative regulator of PKB/Akt and v-Akt at the plasma membrane." in: Science (New York, N.Y.), Vol. 294, Issue 5541, pp. 374-80, 2001 (PubMed).

Parcellier, Tintignac, Zhuravleva et al.: "Carboxy-Terminal Modulator Protein (CTMP) is a mitochondrial protein that sensitizes cells to apoptosis." in: Cellular signalling, Vol. 21, Issue 4, pp. 639-50, 2009 (PubMed).

Zhao, Martin, Bisoffi et al.: "The Akt C-terminal modulator protein is an acyl-CoA thioesterase of the Hotdog-Fold family." in: Biochemistry, Vol. 48, Issue 24, pp. 5507-9, 2009 (PubMed).

Hosts (13), (2)
Reactivities (16), (11), (11)
Applications (15), (12), (10), (3), (3), (2), (1)
Epitopes (4), (2), (2), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN500905
401.50 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
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