Transmembrane Emp24-Like Trafficking Protein 10 (Yeast) (TMED10) (Center) antibody

Details for Product No. ABIN500992
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Antigen
Synonyms tmp21, P24(DELTA), S31I125, S31III125, TMP21, Tmp-21-I, p23, 1110014C03Rik, Tmp21, p24delta1, fe06g04, wu:fb98e10, wu:fe06g04, zgc:85681
Epitope
Center
(22), (6), (5), (5), (2), (2), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(60), (43), (40), (15), (15), (13), (3), (2), (1), (1), (1)
Host
Rabbit
(58), (5), (2), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(53), (25), (21), (16), (10), (2), (1), (1)
Pubmed 4 references available
Quantity 0.1 mg
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Catalog No. ABIN500992
401.50 $
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Immunogen TMP21 antibody was raised against a 18 amino acid peptide from near the center of human TMP21.
Isotype IgG
Specificity This antibody detects TMED10 / TMP21 at Center.
Purification Peptide affinity chromatography
Alternative Name TMED10 / TMP21
Background TMP21 is a ubiquitously expressed protein that is involved in vesicular targeting and protein transport. More recent experiments have shown that it is also a component in the presenilin complex and modulates the gamma-secretase but not theepsilonsecretase cleavage activity of the amyloid precursor protein. The presenilin complex is composed of the proteins APH1, nicastrin, and PEN2 in addition to presenilin-1. Together, these proteins cleave the amyloid precursor protein at what is known as the gamma and epsilon-sites and can lead to the accumulation of the Abeta cleavage product that is associated with Alzheimer’s disease. Co- immunoprecipitation experiments using antibodies against these proteins also yielded TMP21 indicating that TMP21 may play a role in the regulation of this complex. Suppression of TMP21 expression by siRNA in transfected cells caused increased gamma-secretase activity but not epsilon-secretase activity, and increased Abeta production, demonstrating that TMP21 can modulate gammasecretase activity.
Alternate names: 21 kDa transmembrane-trafficking protein, S31I125, Transmembrane emp24 domain- containing protein 10, Transmembrane protein Tmp21
Gene ID 10972
Application Notes ELISA. Western blot: 1 – 2 μg/ml. Immunohistochemistry on paraffin sections. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer PBS containing 0.02% sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
Expiry Date 12 months
Background publications Blum, Feick, Puype et al.: "Tmp21 and p24A, two type I proteins enriched in pancreatic microsomal membranes, are members of a protein family involved in vesicular trafficking." in: The Journal of biological chemistry, Vol. 271, Issue 29, pp. 17183-9, 1996 (PubMed).

Selkoe: "The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer's disease." in: Trends in cell biology, Vol. 8, Issue 11, pp. 447-53, 1999 (PubMed).

Periz, Fortini: "Functional reconstitution of gamma-secretase through coordinated expression of presenilin, nicastrin, Aph-1, and Pen-2." in: Journal of neuroscience research, Vol. 77, Issue 3, pp. 309-22, 2004 (PubMed).

Chen, Hasegawa, Schmitt-Ulms et al.: "TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity." in: Nature, Vol. 440, Issue 7088, pp. 1208-12, 2006 (PubMed).

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