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three Prime Repair Exonuclease 2 (Trex2) (C-Term) antibody

Details for Product No. ABIN501038
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Antigen
Synonyms RGD1562245
Epitope
C-Term
(7), (4)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(14), (6), (6)
Host
Rabbit
(8), (5), (1)
Clonality
Polyclonal
Application
ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(13), (10), (7), (4), (1)
Pubmed 1 reference available
Quantity 0.1 mg
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Catalog No. ABIN501038
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Immunogen TREX2 antibody was raised against a 15 amino acid peptide near the carboxy terminus of human TREX2.
Isotype IgG
Specificity This antibody detects TREX2. The antibody will not cross-react with the related protein TREX1.
Purification Peptide affinity chromatography
Alternative Name TREX2
Background TREX2 is one of two major human 3\' to 5\' exonucleases which are required for checkpoint signaling after DNA damage. While the related protein TREX1 is required for ATR expression and mutations in this gene result in Aicardi-Goutieres syndrome, chilblain lupus, and Cree encephalitis, less is known about TREX2. Like TREX1, TREX2 is ubiquitously expressed in all tissues examined. X-ray crystallography studies of TREX2-single strand DNA complexes revealed that TREX2 binds DNA as a dimer and may act to displace the second DNA strand, suggesting that TREX2 unzips and denatures double stranded DNA and feed the substrate DNA strand into the TREX2 active site. At least two isoforms of TREX2 are known to exist.
Alternate names: 3'-5' exonuclease TREX2, Three prime repair exonuclease 2
Gene ID 11219
NCBI Accession Q9BQ50
Research Area Chromatin and Nuclear Signaling, DNA/RNA
Application Notes ELISA. Western blot: 2 – 4 μg/ml. Immunohistochemistry on paraffin sections. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer PBS containing 0.02% sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
Expiry Date 12 months
Background publications Mazur, Perrino: "Identification and expression of the TREX1 and TREX2 cDNA sequences encoding mammalian 3'-->5' exonucleases." in: The Journal of biological chemistry, Vol. 274, Issue 28, pp. 19655-60, 1999 (PubMed).

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