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Details for Product No. ABIN501120

Mitochondrial Antiviral Signaling Protein (MAVS) (Middle Region) antibody

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Antigen
Synonyms CARDIF, IPS-1, IPS1, VISA, D430028G21Rik, Visa, cardif
Epitope
»Alternatives Middle Region
Reactivity
»Alternatives Human, Mouse (Murine), Rat (Rattus)
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
Pubmed 3 references available
Catalog no. ABIN501120
Quantity 0.1 mg
Price
390.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 8 Business Days
Immunogen VISA antibody was raised against a 17 amino acid peptide from near the center of human VISA.
Isotype IgG
Specificity This antibody detects MAVS at Center.
Purification Affinity chromatography
Alternative Name MAVS
Background Two distinct signaling pathways activate the host innate immunity against viral infection. One pathway is reliant on members of the Toll-like receptor (TLR) family while the other uses the RNA helicase RIG-I as a receptor for intracellular viral double-stranded RNA as a trigger for the immune response. VISA is a mitochondrial membrane protein that was identified as a critical component in the IFN-b signaling pathways that recruits IRF-3 to RIG- I, leading to its activation and that of NF-kappaB. VISA is also thought to interact with other components of the innate immune pathway such as the TLR adapter protein TRIF, TRAF2 and TRAF6. VISA also interacts with the IKKalpha, IKKbeta and IKKepsilon kinases through its C-terminal region. Cleavage of this region by the Hepatitis C virus (HCV) protease allows HCV to escape the host immune system. At least three isoforms of VISA are known to exist.
Alternate names: CARD adapter inducing interferon-beta, Cardif, IPS1, Mitochondrial antiviral-signaling protein, Mitochondrial antiviral-signaling protein, Putative NF-kappa-B-activating protein 031N, VISA, Virus-induced-signaling adapter, nterferon-beta promoter stimulator protein 1
Gene ID 57506
NCBI Accession NP_065797
Research Area Immunology
Application Notes ELISA. Western blot: 0.5 – 1 μg/ml. Immunohistochemistry on paraffin sections. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer PBS containing 0.02% sodium azide
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
Expiry Date 12 months
Background publications Xu, Wang, Han et al.: "VISA is an adapter protein required for virus-triggered IFN-beta signaling." in: Molecular cell, Vol. 19, Issue 6, pp. 727-40, 2005 (PubMed).

Meylan, Curran, Hofmann et al.: "Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus." in: Nature, Vol. 437, Issue 7062, pp. 1167-72, 2005 (PubMed).

Seth, Sun, Chen: "Antiviral innate immunity pathways." in: Cell research, Vol. 16, Issue 2, pp. 141-7, 2006 (PubMed).

Alternatives for antigen "Mitochondrial Antiviral Signaling Protein (MAVS)", type "Antibodies"
Hosts (56), (2)
Reactivities (53), (35), (32), (13), (1), (1), (1)
Applications (49), (20), (18), (13), (10), (4), (2), (2), (2), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (14), (6), (4), (3), (2), (2), (1), (1), (1)
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