X-Box Binding Protein 1 (XBP1) (N-Term) antibody

Details for Product No. ABIN501132
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Antigen
Synonyms treb5, xXBP1, xbp2, XBP1P1, XBPP1, xbp1, TREB5, XBP-1, XBP2, D11Ertd39e, TREB-5, HTF, cb918, id:ibd1195, trebf, wu:fb02h05, wu:fb63f10, xbp1a, xbp1b
Epitope
N-Term
(25), (16), (12), (12), (7), (5), (5), (3), (2), (2), (2), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(124), (58), (41), (15), (15), (13), (4), (1), (1)
Host
Rabbit
(72), (47), (8), (5)
Clonality
Polyclonal
Conjugate
Un-conjugated
(4), (4), (3), (3), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunofluorescence (IF), Western Blotting (WB)
(119), (67), (29), (22), (16), (10), (9), (8), (7), (6), (3), (2), (2), (1)
Pubmed 1 reference available
Quantity 0.1 mg
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Catalog No. ABIN501132
401.50 $
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Immunogen XBP-1 antibody was raised against a 18 amino acid peptide from near the amino terminus of human XBP-1.
Isotype IgG
Cross-Reactivity (Details) Species reactivity (tested):Human, mouse
Purification Affinity chromatography
Alternative Name XBP1 / TREB5
Background X box binding protein 1 (XBP-1) is a key protein in the mammalian unfolded protein response (UPR) that protects the cell against the stress of malfolded proteins in the endoplasmic reticulum (ER) . Upon sensing unfolded proteins, an ER transmembrane endonuclease and kinase termed IRE1p is activated and excises an intron from XBP-1 mRNA. The spliced XBP-1 mRNA results in a 371 amino acid protein (XBP-1s) which is then translocated to the nucleus where it binds to the regulatory elements of downstream genes. Together with other UPR transcription factors such as ATF6, XBP-1 stimulates the production of ER stress proteins including the ER resident protein chaperones glucose regulated protein (GRP) 78 and GRP94 (3,4).Synonyms: Tax-responsive element-binding protein 5, X-box-binding protein 1, XBP-1, XBP2
Gene ID 7494
Application Notes ELISA. Western blot. Immunohistochemistry on paraffin sections: 1 - 2 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer PBS containing 0.02 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store the antibody (in aliquots) at -20 °C.
Background publications Yoshida, Matsui, Yamamoto et al.: "XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor." in: Cell, Vol. 107, Issue 7, pp. 881-91, 2002 (PubMed).

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