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Details for Product No. ABIN501132

X-Box Binding Protein 1 (XBP1) (N-Term) antibody

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Antigen
Synonyms TREB5, XBP-1, XBP2, TREB-5, D11Ertd39e, cb918, treb5, trebf, xbp1a, xbp1b, id:ibd1195, wu:fb02h05, wu:fb63f10, HTF, xXBP1, XBPP1, xbp2, XBP1P1, xbp1
Epitope
»Alternatives N-Term
Reactivity
»Alternatives Human, Mouse (Murine)
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blotting (WB)
Pubmed 1 reference available
Catalog no. ABIN501132
Quantity 0.1 mg
Price
390.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 8 Business Days
Immunogen XBP-1 antibody was raised against a 18 amino acid peptide from near the amino terminus of human XBP-1.
Isotype IgG
Purification Affinity chromatography
Alternative Name XBP1 / TREB5
Background X box binding protein 1 (XBP-1) is a key protein in the mammalian unfolded protein response (UPR) that protects the cell against the stress of malfolded proteins in the endoplasmic reticulum (ER) . Upon sensing unfolded proteins, an ER transmembrane endonuclease and kinase termed IRE1p is activated and excises an intron from XBP-1 mRNA. The spliced XBP-1 mRNA results in a 371 amino acid protein (XBP-1s) which is then translocated to the nucleus where it binds to the regulatory elements of downstream genes. Together with other UPR transcription factors such as ATF6, XBP-1 stimulates the production of ER stress proteins including the ER resident protein chaperones glucose regulated protein (GRP) 78 and GRP94 (3,4).
Alternate names: Tax-responsive element-binding protein 5, X-box-binding protein 1, XBP-1, XBP2
Gene ID 7494
NCBI Accession BAB82982
Application Notes ELISA. Western blot. Immunohistochemistry on paraffin sections: 1 – 2 μg/ml. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS containing 0.02% sodium azide
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store the antibody (in aliquots) at -20°C.
Expiry Date 12 months
Background publications Yoshida, Matsui, Yamamoto et al.: "XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor." in: Cell, Vol. 107, Issue 7, pp. 881-91, 2002 (PubMed).

Alternatives for antigen "X-Box Binding Protein 1 (XBP1)", type "Antibodies"
Hosts (60), (41), (9), (6)
Reactivities (111), (52), (39), (15), (15), (13), (4), (1), (1)
Applications (100), (63), (27), (27), (10), (10), (8), (4), (3), (2), (2), (2), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (19), (14), (7), (6), (4), (3), (2), (2), (2), (2), (1), (1), (1), (1)
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