Ectodysplasin A2 Receptor (EDA2R) antibody

Details for Product No. ABIN501133
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Antigen
Synonyms EDA-A2R, EDAA2R, TNFRSF27, XEDAR, 9430060M22Rik, Xedar, RGD1564025
Reactivity
Human
(64), (13), (11)
Host
Rabbit
(49), (15)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(48), (28), (9), (8), (8), (3), (3), (1)
Pubmed 3 references available
Quantity 0.1 mg
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Catalog No. ABIN501133
401.50 $
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Immunogen XEDAR antibody was raised against recombinant human XEDAR.
Isotype IgG
Specificity This antibody detects EDA2R / TNFRSF27.
Purification Affiinity chromatography
Alternative Name EDA2R / TNFRSF27
Background X-linked ectodysplasin-A2 receptor (XEDAR) is a recently isolated member of the tumor necrosis factor receptor family that is highly expressed during embryonic development and binds to ectodysplatin-A2 (EDA-A2) (1). Two predominantly expressed isoforms, XEDAR-s and XEDAR-L, differ by only a 21-amino region at the juxtamembrane region of the cytoplasmic domain. Neither isoform possesses a death domain and both have been shown to act mainly through TRAF3 and TRAF6 to activate the NF-kappaB and JNK pathways (2). Cells transfected with XEDAR and treated with EDA-A2 cause the assembly of a secondary complex containing FADD, caspase-8 and caspase-10, leading to the activation caspase-8 and caspase-3, and finally apoptosis (3). The EDA-A2-induced apoptosis is dependent on caspase-9 activation, as various pharmacological and genetic inhibitors of caspase-8 blocked apoptosis following EDA-A2 treatment (3).
Alternate names: EDA-A2 receptor, Tumor necrosis factor receptor superfamily member 27, UNQ2448/PRO5727/PRO34080, X-linked ectodysplasin-A2 receptor, XEDAR
Gene ID 60401
Application Notes ELISA. Western blot: 0.5 – 1 μg/ml. Immunohistochemistrry on paraffin sections. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer PBS containing 0.02% sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
Expiry Date 12 months
Background publications Yan, Wang, Hymowitz et al.: "Two-amino acid molecular switch in an epithelial morphogen that regulates binding to two distinct receptors." in: Science (New York, N.Y.), Vol. 290, Issue 5491, pp. 523-7, 2000 (PubMed).

Sinha, Zachariah, Quiñones et al.: "Role of TRAF3 and -6 in the activation of the NF-kappa B and JNK pathways by X-linked ectodermal dysplasia receptor." in: The Journal of biological chemistry, Vol. 277, Issue 47, pp. 44953-61, 2002 (PubMed).

Sinha, Chaudhary: "Induction of apoptosis by X-linked ectodermal dysplasia receptor via a caspase 8-dependent mechanism." in: The Journal of biological chemistry, Vol. 279, Issue 40, pp. 41873-81, 2004 (PubMed).

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