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XIAP antibody (X-Linked Inhibitor of Apoptosis) (C-Term)

Details for Product anti-XIAP Antibody No. ABIN501135, Supplier: Login to see New
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Synonyms BIRC4, api3, birc4, ilp1, miha, xlp2, xxiap, API3, IAP-3, ILP1, MIHA, XLP2, hIAP-3, hIAP3, 1110015C02Rik, Aipa, Api3, Birc4, IAP3, ILP-1, mXIAP, riap3
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(26), (21), (13), (8), (7), (6), (5), (5), (5), (4), (4), (3), (3), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1)
Human, Mouse (Murine)
(159), (55), (37), (6), (4), (4), (2), (2)
(141), (23), (1)
This XIAP antibody is un-conjugated
(6), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(137), (57), (57), (33), (23), (19), (11), (11), (11), (7), (3), (1), (1), (1), (1)
Pubmed 6 references available
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Quantity 0.1 mg
Shipping to United States ( )
Availability Will be delivered in 6 to 8 Business Days
Immunogen XIAP antibody was raised against a synthetic peptide corresponding to 13 amino acids at the C-terminus of human XIAP.
Isotype IgG
Specificity This antibody detects HILP, API3, XIAP at C-term.
Cross-Reactivity (Details) Species reactivity (tested):Human, Mouse.
Purification Immunoaffinity Chromatography
Alternative Name IAP3 / BIRC4 (XIAP Antibody Abstract)
Background Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and can be prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family that binds to and inhibits cell death proteases (1 for review). The X-chromosome linked inhibitor of apoptosis (XIAP) contains 3 baculoviral IAP repeat (BIR) motifs that are essential and sufficient for the binding and inhibition of caspases -3, -7, and -9 (2,3). Upregulation of XIAP expression can protect cells from apoptosis induced by low level radiation, conversely, decreased XIAP expression by antisense targeting resulted in increased cell death following low level radiation (4). Two negative regulators, termed XAF-1 (5) and Smac (6), can bind and inhibit XIAP activity.Synonyms: API3, Baculoviral IAP repeat-containing protein 4, E3 ubiquitin-protein ligase XIAP, HILP, Inhibitor of apoptosis protein 3, X-linked IAP, X-linked inhibitor of apoptosis protein, XIAP
Gene ID 331
NCBI Accession NP_001158
Research Area Cancer, Apoptosis/Necrosis
Pathways Apoptosis, Caspase Cascade in Apoptosis
Application Notes ELISA. Western blot. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Buffer PBS containing 0.02 % Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8 °C.
Supplier Images
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-XIAP antibody (X-Linked Inhibitor of Apoptosis) (C-Term) (ABIN501135) Immunohistochemical staining of Human kidney tissue using AP30993PU-N XIAP antibody a...
Western Blotting (WB) image for anti-XIAP antibody (X-Linked Inhibitor of Apoptosis) (C-Term) (ABIN501135) Western blot analysis of XIAP in Human kidney lysate using AP30993PU-N XIAP antibody ...
Background publications Albaladejo, Alonso, Yus: "Synthesis of indolizines and heterocyclic chalcones catalyzed by supported copper nanoparticles." in: Chemistry (Weinheim an der Bergstrasse, Germany), Vol. 19, Issue 17, pp. 5242-5, 2013 (PubMed).

Schimmer: "Inhibitor of apoptosis proteins: translating basic knowledge into clinical practice." in: Cancer research, Vol. 64, Issue 20, pp. 7183-90, 2004 (PubMed).

Holcik, Yeh, Korneluk et al.: "Translational upregulation of X-linked inhibitor of apoptosis (XIAP) increases resistance to radiation induced cell death." in: Oncogene, Vol. 19, Issue 36, pp. 4174-7, 2000 (PubMed).

Deveraux, Leo, Stennicke et al.: "Cleavage of human inhibitor of apoptosis protein XIAP results in fragments with distinct specificities for caspases." in: The EMBO journal, Vol. 18, Issue 19, pp. 5242-51, 1999 (PubMed).

Deveraux, Takahashi, Salvesen et al.: "X-linked IAP is a direct inhibitor of cell-death proteases." in: Nature, Vol. 388, Issue 6639, pp. 300-4, 1997 (PubMed).

Fukui, Goto, Tabata: "Two antimicrobial flavanones from the leaves of Glycyrrhiza glabra." in: Chemical & pharmaceutical bulletin, Vol. 36, Issue 10, pp. 4174-6, 1989 (PubMed).

Catalog No. ABIN501135
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