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X-Linked Inhibitor of Apoptosis (XIAP) (C-Term) antibody

Details for Product No. ABIN501135
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Antigen
Synonyms BIRC4, api3, birc4, ilp1, miha, xlp2, xxiap, API3, IAP-3, ILP1, MIHA, XLP2, hIAP-3, hIAP3, 1110015C02Rik, Aipa, Api3, Birc4, IAP3, ILP-1, mXIAP, riap3
Epitope
C-Term
(17), (14), (7), (4), (4), (4), (4), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(113), (53), (38), (6), (1)
Host
Rabbit
(103), (16)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(99), (49), (34), (32), (12), (10), (8), (8), (6), (4), (2), (1)
Pubmed 6 references available
Quantity 0.1 mg
Shipping to United States (Change)
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Catalog No. ABIN501135
401.50 $
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Immunogen XIAP antibody was raised against a synthetic peptide corresponding to 13 amino acids at the C-terminus of human XIAP.
Isotype IgG
Specificity This antibody detects HILP, API3, XIAP at C-term.
Purification Immunoaffinity Chromatography
Alternative Name IAP3 / BIRC4
Background Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and can be prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family that binds to and inhibits cell death proteases (1 for review). The X- chromosome linked inhibitor of apoptosis (XIAP) contains 3 baculoviral IAP repeat (BIR) motifs that are essential and sufficient for the binding and inhibition of caspases –3, –7, and –9 (2,3). Upregulation of XIAP expression can protect cells from apoptosis induced by low level radiation, conversely, decreased XIAP expression by antisense targeting resulted in increased cell death following low level radiation (4). Two negative regulators, termed XAF-1 (5) and Smac (6), can bind and inhibit XIAP activity.
Alternate names: API3, Baculoviral IAP repeat-containing protein 4, E3 ubiquitin-protein ligase XIAP, HILP, Inhibitor of apoptosis protein 3, X-linked IAP, X-linked inhibitor of apoptosis protein, XIAP
Gene ID 331
NCBI Accession NP_001158
Research Area Cancer, Apoptosis/Necrosis
Application Notes ELISA. Western blot. Immunohistochemistry on paraffin sections. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer PBS containing 0.02% Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8°C.
Expiry Date 12 months
Background publications Fukui, Goto, Tabata: "Two antimicrobial flavanones from the leaves of Glycyrrhiza glabra." in: Chemical & pharmaceutical bulletin, Vol. 36, Issue 10, pp. 4174-6, 1989 (PubMed).

Deveraux, Takahashi, Salvesen et al.: "X-linked IAP is a direct inhibitor of cell-death proteases." in: Nature, Vol. 388, Issue 6639, pp. 300-4, 1997 (PubMed).

Deveraux, Leo, Stennicke et al.: "Cleavage of human inhibitor of apoptosis protein XIAP results in fragments with distinct specificities for caspases." in: The EMBO journal, Vol. 18, Issue 19, pp. 5242-51, 1999 (PubMed).

Holcik, Yeh, Korneluk et al.: "Translational upregulation of X-linked inhibitor of apoptosis (XIAP) increases resistance to radiation induced cell death." in: Oncogene, Vol. 19, Issue 36, pp. 4174-7, 2000 (PubMed).

Schimmer: "Inhibitor of apoptosis proteins: translating basic knowledge into clinical practice." in: Cancer research, Vol. 64, Issue 20, pp. 7183-90, 2004 (PubMed).

Albaladejo, Alonso, Yus: "Synthesis of indolizines and heterocyclic chalcones catalyzed by supported copper nanoparticles." in: Chemistry (Weinheim an der Bergstrasse, Germany), Vol. 19, Issue 17, pp. 5242-5, 2013 (PubMed).

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