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Details for Product No. ABIN501687

FYVE, RhoGEF and PH Domain Containing 1 (FGD1) (N-Term) antibody

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Antigen
Synonyms AAS, FGDY, MRXS16, ZFYVE3
Epitope
»Alternatives N-Term
Reactivity
»Alternatives Cow (Bovine), Dog (Canine), Human
Host
»Alternatives Rabbit
Clonality Polyclonal
Application
»Alternatives Western Blotting (WB)
Pubmed 1 reference available
Catalog no. ABIN501687
Quantity 50 µg
Price
289.00 $   Plus shipping costs $45.00
Shipping to
Availability Will be delivered in 2 to 3 Business Days
Immunogen The immunogen for anti-FGD1 antibody: synthetic peptide directed towards the N terminal of human FGD1
Sequence HGHRAPGGAGPSEPEHPATNPPGAAPPACADSDPGASEPG LLARRGSGSA
Predicted Reactivity Human : 100%, Bovine : 85%, Dog : 85%, Pig : 85%, Rabbit : 85%
Characteristics This is a rabbit polyclonal antibody against FGD1. It was validated on Western Blot using a cell lysate as a positive control. We strive to provide antibodies covering each member of a whole protein family of your interest.
Purification Affinity Purified
Alternative Name FGD1
Background FGD1 contains Dbl (DH) and pleckstrin (PH) homology domains. It can bind specifically to the Rho family GTPase Cdc42Hs and stimulate the GDP-GTP exchange of the isoprenylated form of Cdc42Hs. It also stimulates the mitogen activated protein kinase cascade leading to c-Jun kinase SAPK/JNK1 activation. FGD1 has an essential role in embryonic development, and FGD1 gene mutations result in the human developmental disorder, Aarskog-Scott syndrome.FGD1 contains Dbl (DH) and pleckstrin (PH) homology domains. It can bind specifically to the Rho family GTPase Cdc42Hs and stimulate the GDP-GTP exchange of the isoprenylated form of Cdc42Hs. It also stimulates the mitogen activated protein kinase cascade leading to c-Jun kinase SAPK/JNK1 activation. FGD1 has an essential role in embryonic development, and FGD1 gene mutations result in the human developmental disorder, Aarskog-Scott syndrome.
Molecular Weight 106kDa
Gene ID 2245
NCBI Accession NP_004454, NM_004463
UniProt P98174
Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water
Concentration 1mg/mL
Buffer Final anti-FGD1 antibody concentration is 1 mg/mL in PBS buffer.
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Background publications Bottani, Orrico, Galli et al.: "Unilateral focal polymicrogyria in a patient with classical Aarskog-Scott syndrome due to a novel missense mutation in an evolutionary conserved RhoGEF domain of the faciogenital dysplasia gene FGD1." in: American journal of medical genetics. Part A, Vol. 143A, Issue 19, pp. 2334-8, 2007 (PubMed).

Alternatives for antigen "FYVE, RhoGEF and PH Domain Containing 1 (FGD1)", type "Antibodies"
Hosts (6)
Reactivities (6), (1), (1), (1), (1)
Applications (5), (1), (1)
Epitopes (2), (1)
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