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FYVE, RhoGEF and PH Domain Containing 1 (FGD1) (N-Term) antibody

Details for Product No. ABIN501687
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Antigen
Synonyms AAS, FGDY, MRXS16, ZFYVE3
Epitope
N-Term
(2), (1)
Reactivity
Cow (Bovine), Dog (Canine), Human
(6), (1), (1), (1), (1)
Host
Rabbit
(6)
Clonality
Polyclonal
Application
Western Blotting (WB)
(5), (1)
Pubmed 1 reference available
Quantity 50 µg
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Availability Will be delivered in 2 to 3 Business Days
Catalog No. ABIN501687
289.00 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen Synthetic peptide directed towards the N terminal of human FGD1
Sequence HGHRAPGGAGPSEPEHPATNPPGAAPPACADSDPGASEPG LLARRGSGSA
Predicted Reactivity Human : 100 %, Bovine : 80 %, Dog : 80 %, Pig : 80 %, Rabbit : 80 %
Characteristics This is a rabbit polyclonal antibody against FGD1. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name FGD1
Background FGD1 contains Dbl (DH) and pleckstrin (PH) homology domains. It can bind specifically to the Rho family GTPase Cdc42Hs and stimulate the GDP-GTP exchange of the isoprenylated form of Cdc42Hs. It also stimulates the mitogen activated protein kinase cascade leading to c-Jun kinase SAPK/JNK1 activation. FGD1 has an essential role in embryonic development, and FGD1 gene mutations result in the human developmental disorder, Aarskog-Scott syndrome.FGD1 contains Dbl (DH) and pleckstrin (PH) homology domains. It can bind specifically to the Rho family GTPase Cdc42Hs and stimulate the GDP-GTP exchange of the isoprenylated form of Cdc42Hs. It also stimulates the mitogen activated protein kinase cascade leading to c-Jun kinase SAPK/JNK1 activation. FGD1 has an essential role in embryonic development, and FGD1 gene mutations result in the human developmental disorder, Aarskog-Scott syndrome.
Molecular Weight 106 kDa
Gene ID 2245
NCBI Accession NM_004463, NP_004454
UniProt P98174
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 961 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Background publications Bottani, Orrico, Galli et al.: "Unilateral focal polymicrogyria in a patient with classical Aarskog-Scott syndrome due to a novel missense mutation in an evolutionary conserved RhoGEF domain of the faciogenital dysplasia gene FGD1." in: American journal of medical genetics. Part A, Vol. 143A, Issue 19, pp. 2334-8, 2007 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN501687
289.00 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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