Microtubule Associated Tumor Suppressor 1 (MTUS1) (Middle Region) antibody

Details for Product No. ABIN502510
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Antigen
Synonyms ATBP, ATIP, ICIS, MP44, MTSG1, ATIP4, Atip3b, Mtsg1, fbx27, AI481402, ATBP135, Atip1, B430010I23Rik, B430305I03Rik, C85752, Cctsg1-440, MD44, mKIAA1288
Epitope
Middle Region
(7), (3), (2), (1), (1), (1), (1)
Reactivity
Mouse (Murine), Rat (Rattus), Cow (Bovine), Dog (Canine), Xenopus laevis, Human
(18), (4), (3), (2), (1), (1)
Host
Rabbit
(9), (9)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(17), (11), (2)
Pubmed 1 reference available
Quantity 50 µg
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Catalog No. ABIN502510
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Immunogen Synthetic peptide directed towards the middle region of human MTUS1
Sequence KRLSMENEEL LWKLHNGDLC SPKRSPTSSA IPLQSPRNSG SFPSPSISPR
Predicted Reactivity Bovine : 100 %, Dog : 100 %, Human : 100 %, Pig : 100 %, Mouse : 90 %, Rat : 90 %, Guinea pig : 80 %, Rabbit : 80 %, African clawed frog : 70 %
Characteristics This is a rabbit polyclonal antibody against MTUS1. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name MTUS1
Background MTUS1 contains a C-terminal domain and is able to interact with the angiotension II (AT2) receptor and a large coiled-coil region allowing dimerization. One of the isoforms has been shown to be a mitochondrial protein that acts as a tumor suppressor and partcipates in AT2 signaling pathways. Other isoforms may be nuclear or transmembrane proteins but it has not been determined whether they also participate in AT2 signaling pathways. This gene encodes a protein which contains a C-terminal domain able to interact with the angiotension II (AT2) receptor and a large coiled-coil region allowing dimerization. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the transcript variants has been shown to encode a mitochondrial protein that acts as a tumor suppressor and partcipates in AT2 signaling pathways. Other variants may encode nuclear or transmembrane proteins but it has not been determined whether they also participate in AT2 signaling pathways.
Molecular Weight 141 kDa
Gene ID 57509
NCBI Accession NP_001001924, NM_001001924
UniProt Q9ULD2
Research Area Cancer, Transcription Factors
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 1270 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
anti-Microtubule Associated Tumor Suppressor 1 (MTUS1) (Middle Region) antibody WB Suggested Anti-MTUS1 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:1562500
Positive Control: Hela cell lysate
anti-Microtubule Associated Tumor Suppressor 1 (MTUS1) (Middle Region) antibody (2) anti-Microtubule Associated Tumor Suppressor 1 (MTUS1) (Middle Region) antibody (Image 2)
anti-Microtubule Associated Tumor Suppressor 1 (MTUS1) (Middle Region) antibody (3) anti-Microtubule Associated Tumor Suppressor 1 (MTUS1) (Middle Region) antibody (Image 3)
Background publications Uhl, Liu, Drgon et al.: "Molecular genetics of successful smoking cessation: convergent genome-wide association study results." in: Archives of general psychiatry, Vol. 65, Issue 6, pp. 683-93, 2008 (PubMed).

Validation Images
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