GZMK antibody (Middle Region)

Catalog No. ABIN502602

The Rabbit Polyclonal anti-GZMK antibody (ABIN502602) specifically detects GZMK in WB. The antibody is reactive with Human and Pig samples.

Quick Overview for GZMK antibody (Middle Region) (ABIN502602)

Target: GZMK (Granzyme K (Granzyme 3, Tryptase II) (GZMK))

Reactivity: Human, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GZMK antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-GZMK Antibody

Binding Specificity: Middle Region

Sequence: LRSGTKCKVT GWGATDPDSL RPSDTLREVT VTVLSRKLCN SQSYYNGDPF

Predicted Reactivity: Human: 100%, Pig: 93%

Characteristics: This is a rabbit polyclonal antibody against GZMK. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human GZMK

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

Antigen size: 264 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for GZMK

Target: GZMK (Granzyme K (Granzyme 3, Tryptase II) (GZMK))

Alternative Name: GZMK

Background: GZMK is a member of a group of related serine proteases from the cytoplasmic granules of cytotoxic lymphocytes. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein described here lacks consensus sequences for N-glycosylation present in other granzymes. This gene product is a member of a group of related serine proteases from the cytoplasmic granules of cytotoxic lymphocytes. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein described here lacks consensus sequences for N-glycosylation present in other granzymes. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: TRYP2
Protein Interaction Partner: SET, HMGB2, APEX1, PNKP, LIG4, HNRNPK, GOLGA2, ACTG1, TUBB3, NPLOC4, VCP, UFD1L,
Protein Size: 264

Molecular Weight: 26 kDa

Gene ID: 3003

NCBI Accession: NM_002104, NP_002095

UniProt: P49863