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Details for Product No. ABIN502640

Patched 2 (PTCH2) (N-Term) antibody

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Antigen
Synonyms PTC2, ptc2, Ptch1, ptc-2, xptc-2, xptch-2, patched-2, ptch2
Epitope
»Alternatives N-Term
Reactivity
»Alternatives Mouse (Murine), Cow (Bovine), Dog (Canine), Human
Host
»Alternatives Rabbit
Clonality Polyclonal
Application
»Alternatives Western Blotting (WB)
Pubmed 1 reference available
Catalog no. ABIN502640
Quantity 50 µg
Price
289.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen The immunogen for anti-PTCH2 antibody: synthetic peptide directed towards the N terminal of human PTCH2
Sequence LAQEALPENASQQIHAFSSTTLDDILHAFSEVSAARVVGG YLLMLAYACV
Predicted Reactivity Bovine : 100%, Dog : 100%, Horse : 100%, Rabbit : 85%
Characteristics This is a rabbit polyclonal antibody against PTCH2. It was validated on Western Blot using a cell lysate as a positive control. We strive to provide antibodies covering each member of a whole protein family of your interest.
Purification Affinity Purified
Alternative Name PTCH2
Background PTCH2 is a member of the patched protein family. The patched protein is the receptor for sonic hedgehog, a secreted molecule implicated in the formation of embryonic structures and in tumorigenesis. The gene encoding PTCH2 is shown to be mutated in a medulloblastoma and in a basal cell carcinoma, suggesting that it plays a role in the development of some tumors. This gene encodes a member of the patched gene family. The patched protein is the receptor for sonic hedgehog, a secreted molecule implicated in the formation of embryonic structures and in tumorigenesis. This gene is shown to be mutated in a medulloblastoma and in a basal cell carcinoma, suggesting that it plays a role in the development of some tumors. Alternative transcript variants have been described, but their biological function has not been determined.
Molecular Weight 130kDa
Gene ID 8643
NCBI Accession NP_003729, NM_003738
UniProt Q9Y6C5
Research Area Cancer, Cell Cycle, Transcription Factors
Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water
Concentration 1mg/mL
Buffer Final anti-PTCH2 antibody concentration is 1 mg/mL in PBS buffer.
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Background publications Gregory, Barlow, McLay et al.: "The DNA sequence and biological annotation of human chromosome 1." in: Nature, Vol. 441, Issue 7091, pp. 315-21, 2006 (PubMed).

Alternatives for antigen "Patched 2 (PTCH2)", type "Antibodies"
Hosts (18), (1)
Reactivities (13), (5), (4), (2), (2), (1)
Applications (16), (13), (2), (2), (2), (1), (1), (1)
Epitopes (4), (3), (2), (1), (1), (1)
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