Patched 2 (PTCH2) (N-Term) antibody

Details for Product No. ABIN502640
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Antigen
Synonyms Ptch1, ptc2, ptc-2, xptc-2, xptch-2, patched-2, ptch2, lep, ptc1, PTC2
Epitope
N-Term
(6), (5), (2), (1), (1), (1)
Reactivity
Mouse (Murine), Cow (Bovine), Dog (Canine), Human
(13), (8), (3), (2), (1)
Host
Rabbit
(20), (2)
Clonality
Polyclonal
Application
Western Blotting (WB)
(15), (13), (2), (1), (1), (1), (1)
Pubmed 1 reference available
Quantity 50 μg
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Catalog No. ABIN502640
289.00 $
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Immunogen Synthetic peptide directed towards the N terminal of human PTCH2
Sequence LAQEALPENA SQQIHAFSST TLDDILHAFS EVSAARVVGG YLLMLAYACV
Predicted Reactivity Bovine : 100 %, Dog : 100 %, Horse : 100 %, Rabbit : 80 %
Characteristics This is a rabbit polyclonal antibody against PTCH2. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name PTCH2
Background PTCH2 is a member of the patched protein family. The patched protein is the receptor for sonic hedgehog, a secreted molecule implicated in the formation of embryonic structures and in tumorigenesis. The gene encoding PTCH2 is shown to be mutated in a medulloblastoma and in a basal cell carcinoma, suggesting that it plays a role in the development of some tumors. This gene encodes a member of the patched gene family. The patched protein is the receptor for sonic hedgehog, a secreted molecule implicated in the formation of embryonic structures and in tumorigenesis. This gene is shown to be mutated in a medulloblastoma and in a basal cell carcinoma, suggesting that it plays a role in the development of some tumors. Alternative transcript variants have been described, but their biological function has not been determined.
Molecular Weight 130 kDa
Gene ID 8643
NCBI Accession NM_003738, NP_003729
UniProt Q9Y6C5
Research Area Cancer, Cell Cycle, Transcription Factors
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 1203 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Background publications Gregory, Barlow, McLay et al.: "The DNA sequence and biological annotation of human chromosome 1. ..." in: Nature, Vol. 441, Issue 7091, pp. 315-21, 2006 (PubMed).

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