FIP200 antibody (C-Term)

Catalog No. ABIN503160

This anti-FIP200 antibody is a Rabbit Polyclonal antibody detecting FIP200 in WB and IHC. Suitable for Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse and Zebrafish (Danio rerio).

Quick Overview for FIP200 antibody (C-Term) (ABIN503160)

Target: FIP200 (RB1CC1) (RB1-Inducible Coiled-Coil 1 (RB1CC1))

Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FIP200 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-FIP200 Antibody

Binding Specificity: C-Term

Sequence: SGASRRPWVL GKVMEKEYCQ AKKAQNRFKV PLGTKFYRVK AVSWNKKV

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rat: 100%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against RB1CC1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human RB1CC1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 1591 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for FIP200

Target: FIP200 (RB1CC1) (RB1-Inducible Coiled-Coil 1 (RB1CC1))

Alternative Name: RB1CC1

Background: RB1CC1 is implicated in the regulation of RB1 expression. It functions as a DNA-binding transcription factor. RB1CC1 is a potent regulator of the RB1 pathway and a mediator that plays a crucial role in muscular differentiation. The expression of RB1CC1 is, thus, a prerequisite for myogenic differentiation. RB1CC1 is frequently mutated in breast cancer and shows characteristics of a classical tumor suppressor gene.
Alias Symbols: CC1, DRAGOU14, FIP200
Protein Interaction Partner: ATG16L1, SESN2, ATG5, UBC, EXOC1, DYRK2, PINK1, CALCOCO2, RFWD2, CTNNB1, GABARAPL1, GABARAP, VHL, RNF111, SMARCB1, SKIL, SKI, TBKBP1, TP53, ATG13, ULK2, SAFB2, ULK1, SAFB, RPA2, RPA1, PRKAB2, PRKAA2, HSBP1, MAP1LC3C, SMCR8, ATG101, YLPM1, TBK1, RBMX, PTK2
Protein Size: 1591

Molecular Weight: 183 kDa

Gene ID: 9821

NCBI Accession: NM_001083617, NP_001077086

UniProt: Q8TDY2

Pathways: Regulation of Cell Size, Autophagy