Casein Kinase 1, epsilon (CSNK1E) (N-Term) antibody

Details for Product No. ABIN503293
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Antigen
Synonyms CKIepsilon, ck1-epsilon, ck1epsilon, ckie, CKIe, hckie, dco, fj38c01, wu:fj38c01, wu:fj62a04, zgc:77310, CSNK1E, HCKIE, AI426939, AI551861, AW457082, CK1epsilon, KC1epsilon, tau
Epitope
N-Term
(15), (4), (4), (4), (4), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Mouse (Murine), Rat (Rattus), Fruit Fly (Drosophila melanogaster), Dog (Canine), Xenopus laevis, Human
(52), (23), (7), (5), (2), (1), (1)
Host
Rabbit
(46), (7), (5), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (3), (3), (2), (2), (2)
Application
Western Blotting (WB)
(54), (41), (24), (15), (10), (4), (3), (1)
Pubmed 1 reference available
Quantity 50 µg
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Catalog No. ABIN503293
289.00 $
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  • +1 404 474 4654
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Immunogen Synthetic peptide directed towards the N terminal of human CSNK1E
Sequence MELRVGNKYR LGRKIGSGSF GDIYLGANIA SGEEVAIKLE CVKTKHPQLH
Predicted Reactivity African clawed frog : 100 %, Bovine : 100 %, Chicken : 100 %, Dog : 100 %, Guinea pig : 100 %, Human : 100 %, Mouse : 100 %, Pig : 100 %, Rat : 100 %, Zebrafish : 90 %
Characteristics This is a rabbit polyclonal antibody against CSNK1E. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name CSNK1E
Background Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. CSNK1E can phosphorylate a large number of proteins. CSNK1E participates in Wnt signaling and is the central component of the circadian clock. It may act as a negative regulator of circadian rhythmicity by phosphorylating PER1 and PER2. CSNK1E inhibits cytokine-induced granuloytic differentiation.The protein encoded by this gene is a serine/threonine protein kinase and a member of the casein kinase I protein family, whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein is found in the cytoplasm as a monomer and can phosphorylate a variety of proteins, including itself. This protein has been shown to phosphorylate period, a circadian rhythm protein. Two transcript variants encoding the same protein have been found for this gene.
Molecular Weight 47 kDa
Gene ID 1454
NCBI Accession NM_001894, NP_001885
UniProt P49674
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 416 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
anti-Casein Kinase 1, epsilon (CSNK1E) (N-Term) antibody WB Suggested Anti-CSNK1E Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:62500
Positive Control: THP-1 cell lysate
Product cited in: Levran, Londono, OHara et al.: "Genetic susceptibility to heroin addiction: a candidate gene association study." in: Genes, brain, and behavior, Vol. 7, Issue 7, pp. 720-9, 2009 (PubMed).

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