ANGPTL2 antibody (N-Term)

Catalog No. ABIN503583

Cited in 2+ publications. The Rabbit Polyclonal anti-ANGPTL2 antibody (ABIN503583) specifically detects ANGPTL2 in WB. The antibody is reactive with Human, Rat, Mouse, Cow, Dog, Guinea Pig, Horse, Rabbit and Zebrafish (Danio rerio) samples.

Quick Overview for ANGPTL2 antibody (N-Term) (ABIN503583)

Target: ANGPTL2 (Angiopoietin-Like 2 (ANGPTL2))

Reactivity: Human, Rat, Mouse, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ANGPTL2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-ANGPTL2 Antibody

Binding Specificity: N-Term

Purpose: ANGPTL2 Antibody - N-terminal region

Sequence: NSKEPEVLLE NRVHKQELEL LNNELLKQKR QIETLQQLVE VDGGIVSEVK

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against ANGPTL2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human ANGPTL2

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP54835-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

References for anti-ANGPTL2 antibody (ABIN503583)

Doblinger, Höcherl, Mederle, Kattler, Walter, Hansen, Jensen, Castrop: "Angiotensin AT1 receptor-associated protein Arap1 in the kidney vasculature is suppressed by angiotensin II." in: American journal of physiology. Renal physiology, Vol. 302, Issue 10, pp. F1313-24, (2012) (PubMed).

Sun, Zheng, Chen, Zeng, Liu, Li: "Enhanced expression of ANGPTL2 in the microvascular lesions of diabetic glomerulopathy." in: Nephron. Experimental nephrology, Vol. 105, Issue 4, pp. e117-23, (2007) (PubMed).

Target Details for ANGPTL2

Target: ANGPTL2 (Angiopoietin-Like 2 (ANGPTL2))

Alternative Name: ANGPTL2

Background:

Background Information: Angiopoietins are members of the vascular endothelial growth factor family and the only known growth factors largely specific for vascular endothelium. Angiopoietin-1, angiopoietin-2, and angiopoietin-4 participate in the formation of blood vessels. ANGPTL2 is a secreted glycoprotein with homology to the angiopoietins and may exert a function on endothelial cells through autocrine or paracrine action.Angiopoietins are members of the vascular endothelial growth factor family and the only known growth factors largely specific for vascular endothelium. Angiopoietin-1, angiopoietin-2, and angiopoietin-4 participate in the formation of blood vessels. ANGPTL2 protein is a secreted glycoprotein with homology to the angiopoietins and may exert a function on endothelial cells through autocrine or paracrine action. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-127 AL598400.1 2-128 128-451 AL598400.1 129-452 452-2289 BC012368.1 325-2162 2290-3572 AK074726.1 1294-2576

Gene Name: Angiopoietin-like 2

Alternative Symbols: ARP2, HARP

Protein Name: Angiopoietin-related protein 2

Molecular Weight: 57kDa

Gene ID: 23452

NCBI Accession: NP_036230

UniProt: Q9UKU9