Adrenocortical Dysplasia Homolog (Mouse) (ACD) antibody

Antigen: Adrenocortical Dysplasia Homolog (Mouse) (ACD)

Synonyms: PIP1, PTOP, TPP1, TINT1, MGC116400, ACD

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Conjugate: Un-conjugated

Application: Western Blotting (WB)

Catalog no.: ABIN504441

Additional Information

Alternative name: ACD

Gene ID: ACD

UniProt: Q96AP0

Immunogen: The immunogen for anti-ACD antibody: synthetic peptide directed towards the C terminal of human ACD

Sequence: SSQPSPAICSAPATLTPRSPHASRTPSSPLQSCTPSLSPR SHVPSPHQAL

Cross-Reactivity: Human

Format: Lyophilized

Reconstitution: Add 50 µl of distilled water. Final anti-ACD antibody concentration is 1 mg/ml.

Description: ACD is a protein that is involved in telomere function. This protein is one of six core proteins in the telosome/shelterin telomeric complex, which functions to maintain telomere length and to protect telomere ends. Through its interaction with other components, this protein plays a key role in the assembly and stabilization of this complex, and it mediates the access of telomerase to the telomere.This gene encodes a protein that is involved in telomere function. This protein is one of six core proteins in the telosome/shelterin telomeric complex, which functions to maintain telomere length and to protect telomere ends. Through its interaction with other components, this protein plays a key role in the assembly and stabilization of this complex, and it mediates the access of telomerase to the telomere. Multiple transcript variants encoding different isoforms have been found for this gene. This gene, which is also referred to as TPP1, is distinct from the unrelated TPP1 gene on chromosome 11, which encodes tripeptidyl-peptidase I.

Characteristics: Antigen Size: 544 amino acids

Molecular Weight: 58kDa

Application Details

Application Notes: WB Suggested Anti-ACD Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:62500
Positive Control: Human brain.

Purification: Affinity Purified

Buffer: PBS

Storage (Long Term): For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.

Storage (Short Term): Any unfrozen and/or unused material can be stored at 4°C for short term use (< 1 week), and should not be re-frozen.

Restrictions: For Research Use only

Images

WB Suggested Anti-ACD Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:62500
Positive Control: Human brain

Publications

Product: Hockemeyer, Palm, Else et al.: "Telomere protection by mammalian Pot1 requires interaction with Tpp1." in: Nature structural & molecular biology, Vol. 14, Issue 8, pp. 754-61, 2007 (PubMed).