TNFSF14 antibody (Middle Region)

Catalog No. ABIN504580

This Rabbit Polyclonal antibody specifically detects TNFSF14 in WB. It exhibits reactivity toward Dog.

Quick Overview for TNFSF14 antibody (Middle Region) (ABIN504580)

Target: TNFSF14 (Tumor Necrosis Factor (Ligand) Superfamily, Member 14 (TNFSF14))

Reactivity: Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TNFSF14 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-TNFSF14 Antibody

Binding Specificity: Middle Region

Sequence: ATSSSRVWWD SSFLGGVVHL EAGEKVVVRV LDERLVRLRD GTRSYFGAFM

Predicted Reactivity: Dog: 92%

Characteristics: This is a rabbit polyclonal antibody against TNFSF14. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human TNFSF14

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 240 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for TNFSF14

Target: TNFSF14 (Tumor Necrosis Factor (Ligand) Superfamily, Member 14 (TNFSF14))

Alternative Name: TNFSF14

Background: TNFSF14 is the cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B TNFSF14 modulates its effects. TNFSF14 activates NFKB, stimulates the proliferation of T-cells, and inhibits growth of the adenocarcinoma HT-29. TNFSF14 acts as a receptor for Herpes simplex virus.The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF14, which is a member of the tumor necrosis factor receptor superfamily, and which is also known as a herpesvirus entry mediator (HVEM). This protein may function as a costimulatory factor for the activation of lymphoid cells and as a deterrent to infection by herpesvirus. This protein has been shown to stimulate the proliferation of T cells, and trigger apoptosis of various tumor cells. This protein is also reported to prevent tumor necrosis factor alpha mediated apoptosis in primary hepatocyte. Two alternatively spliced transcript variant encoding distinct isoforms have been reported.
Alias Symbols: CD258, HVEML, LIGHT, LTg, TR2
Protein Interaction Partner: APP, TNFRSF6B, TNFRSF14, LTBR, LTB, DIABLO, TRAF3, TRAF2, BIRC2,
Protein Size: 240

Molecular Weight: 22 kDa

Gene ID: 8740

NCBI Accession: NM_003807, NP_003798

UniProt: O43557

Pathways: Cancer Immune Checkpoints