anti-RIPK2 antibody (Receptor-Interacting Serine-threonine Kinase 2) (Middle Region)

Details for Product anti-RIPK2 Antibody No. ABIN504581, Supplier: Login to see New
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Antigen
Synonyms RIPK2, 2210420D18Rik, CARD3, CARDIAK, CCK, D4Bwg0615e, RICK, RIP2, GIG30
Alternatives
Epitope
Middle Region
(31), (18), (11), (9), (5), (5), (3), (3), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Chicken, Cow (Bovine), Dog (Canine), Human, Mouse (Murine), Rat (Rattus)
(139), (35), (19), (3), (3), (2), (2), (1)
Host
Rabbit
(119), (15), (5)
Clonality
Polyclonal
Conjugate
This RIPK2 antibody is un-conjugated
(5), (4), (3), (2), (2), (2)
Application
Immunofluorescence (IF), Western Blotting (WB)
(133), (68), (43), (19), (14), (13), (3), (3), (3), (2), (2), (1)
Pubmed 1 reference available
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Quantity 50 μg
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Immunogen Synthetic peptide directed towards the middle region of human RIPK2
Sequence LRQERKRPLL DLHIELNGYM YDWNSRVSAK EKYYVWLQHT LRKKLILSYT
Predicted Reactivity Bovine : 85 %, Dog : 85 %, Horse : 85 %, Human : 85 %, Rabbit : 85 %, Chicken : 75 %, Guinea pig : 75 %, Mouse : 75 %, Rat : 75 %
Characteristics This is a rabbit polyclonal antibody against RIPK2. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name RIPK2 (RIPK2 Antibody Abstract)
Background RIPK2 is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. It contains a C-terminal caspase activation and recruitment domain (CARD), and is a component of signaling complexes in both the innate and adaptive immune pathways. It is a potent activator of NF-kappaB and inducer of apoptosis in response to various stimuli.This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein contains a C-terminal caspase activation and recruitment domain (CARD), and is a component of signaling complexes in both the innate and adaptive immune pathways. It is a potent activator of NF-kappaB and inducer of apoptosis in response to various stimuli.
Molecular Weight 61 kDa
Gene ID 8767
NCBI Accession NM_003821, NP_003812
UniProt O43353
Research Area Apoptosis/Necrosis, Signaling
Pathways TCR Signaling, Neurotrophin Signaling Pathway
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 540 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
Western Blotting (WB) image for anti-RIPK2 antibody (Receptor-Interacting Serine-threonine Kinase 2) (Middle Region) (ABIN504581) WB Suggested Anti-RIPK2 Antibody Titration: 0.2-1 ug/ml
ELISA Titer:
Immunofluorescence (IF) image for anti-RIPK2 antibody (Receptor-Interacting Serine-threonine Kinase 2) (Middle Region) (ABIN504581) Sample Type: Rat thyrocytes-FRTL-5

Primary Antibody Dilution: 1:100
...
Background publications Hasegawa, Fujimoto, Lucas et al.: "A critical role of RICK/RIP2 polyubiquitination in Nod-induced NF-kappaB activation." in: The EMBO journal, Vol. 27, Issue 2, pp. 373-83, 2008 (PubMed).

Catalog No. ABIN504581
$289.00
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