RIPK2 antibody (Middle Region)

Catalog No. ABIN504581

Product Details anti-RIPK2 Antibody

Target: RIPK2 (Receptor-Interacting Serine-threonine Kinase 2 (RIPK2))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Cow, Dog, Horse, Rabbit, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RIPK2 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Sequence: LRQERKRPLL DLHIELNGYM YDWNSRVSAK EKYYVWLQHT LRKKLILSYT

Predicted Reactivity: Cow: 85%, Dog: 85%, Guinea Pig: 78%, Horse: 85%, Human: 85%, Mouse: 78%, Rabbit: 84%, Rat: 78%

Characteristics: This is a rabbit polyclonal antibody against RIPK2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human RIPK2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 540 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for RIPK2

Target: RIPK2 (Receptor-Interacting Serine-threonine Kinase 2 (RIPK2))

Alternative Name: RIPK2 (RIPK2 Products)

Synonyms: RIPK2 antibody, 2210420D18Rik antibody, CARD3 antibody, CARDIAK antibody, CCK antibody, D4Bwg0615e antibody, RICK antibody, RIP2 antibody, GIG30 antibody, receptor interacting serine/threonine kinase 2 antibody, receptor (TNFRSF)-interacting serine-threonine kinase 2 antibody, receptor-interacting serine-threonine kinase 2 antibody, RIPK2 antibody, Ripk2 antibody

Background: RIPK2 is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. It contains a C-terminal caspase activation and recruitment domain (CARD), and is a component of signaling complexes in both the innate and adaptive immune pathways. It is a potent activator of NF-kappaB and inducer of apoptosis in response to various stimuli.This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein contains a C-terminal caspase activation and recruitment domain (CARD), and is a component of signaling complexes in both the innate and adaptive immune pathways. It is a potent activator of NF-kappaB and inducer of apoptosis in response to various stimuli. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: CARD3, CARDIAK, CCK, GIG30, RICK, RIP2
Protein Interaction Partner: RIPK2, XIAP, UBC, TRAF3, KDM3A, PRMT2, PELI3, NOD1, MAP3K7, CHUK, LRRK2, NOD2, TRAF4, TRAF6, MAP3K4, CASP12, NAT16, RNF31, RIPK1, MAVS, TRAF2, TAB2, TAB1, IKBKG, BIRC3, BIRC2, CARD16, CARD6, UBE2I, SMURF1, CFLAR, BCL10, TLR4, TLR2, TRAF5, CASP8, TRAF1, SM
Protein Size: 540

Molecular Weight: 61 kDa

Gene ID: 8767

NCBI Accession: NM_003821, NP_003812

UniProt: O43353

Pathways: TCR Signaling, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Toll-Like Receptors Cascades