SRD5A1 antibody (AA 1-259)

Catalog No. ABIN520464

Cited in 3+ publications. The Rabbit Polyclonal anti-SRD5A1 antibody (ABIN520464) specifically detects SRD5A1 in WB. The antibody is reactive with Human samples.

Quick Overview for SRD5A1 antibody (AA 1-259) (ABIN520464)

Target: SRD5A1 (Steroid-5-alpha-Reductase, alpha Polypeptide 1 (3-Oxo-5 alpha-Steroid delta 4-Dehydrogenase alpha 1) (SRD5A1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SRD5A1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-SRD5A1 Antibody

Binding Specificity: AA 1-259

Purpose: Rabbit polyclonal antibody raised against a full-length human SRD5A1 protein.

Sequence: MATATGVAEE RLLAALAYLQ CAVGCAVFAR NRQTNSVYGR HALPSHRLRV PARAAWVVQE LPSLALPLYQ YASESAPRLR SAPNCILLAM FLVHYGHRCL IYPFLMRGGK PMPLLACTMA IMFCTCNGYL QSRYLSHCAV YADDWVTDPR FLIGFGLWLT GMLINIHSDH ILRNLRKPGD TGYKIPRGGL FEYVTAANYF GEIMEWCGYA LASWSVQGAA FAFFTFCFLS GRAKEHHEWY LRKFEEYPKF RKIIIPFLF

Cross-Reactivity: Human

Characteristics: Antibody reactive against mammalian transfected lysate.

Immunogen: SRD5A1 (NP_001038.1, 1 a.a. ~ 259 a.a) full-length human protein.

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: In 1x PBS, pH 7.4

Handling Advice: Aliquot to avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

References for anti-SRD5A1 antibody (ABIN520464)

Horii, Sato, Mesaki, Iemitsu: "Increased Muscular 5α-Dihydrotestosterone in Response to Resistance Training Relates to Skeletal Muscle Mass and Glucose Metabolism in Type 2 Diabetic Rats." in: PLoS ONE, Vol. 11, Issue 11, pp. e0165689, (2016) (PubMed).

Park, Aizawa, Iemitsu, Sato, Akimoto, Agata, Maeda, Ezawa, Omi: "DHEA administration activates local bioactive androgen metabolism in cancellous site of tibia of ovariectomized rats." in: Calcified tissue international, Vol. 89, Issue 2, pp. 105-10, (2011) (PubMed).

Chang, Li, Papari-Zareei, Watumull, Zhao, Auchus, Sharifi: "Dihydrotestosterone synthesis bypasses testosterone to drive castration-resistant prostate cancer." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 108, Issue 33, pp. 13728-33, (2011) (PubMed).

Target Details for SRD5A1

Target: SRD5A1 (Steroid-5-alpha-Reductase, alpha Polypeptide 1 (3-Oxo-5 alpha-Steroid delta 4-Dehydrogenase alpha 1) (SRD5A1))

Alternative Name: SRD5A1

Background: Full Gene Name: steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
Synonyms:

Gene ID: 6715

NCBI Accession: NM_001047

Pathways: Metabolism of Steroid Hormones and Vitamin D, Steroid Hormone Biosynthesis, Response to Growth Hormone Stimulus, C21-Steroid Hormone Metabolic Process