BRMS1 antibody (AA 1-246)

Catalog No. ABIN565191

Cited in 8+ publications. The Mouse Monoclonal anti-BRMS1 antibody (Clone 2D4-2G11) (ABIN565191) specifically detects BRMS1 in WB, ELISA and IP. The antibody is reactive with Human samples.

Quick Overview for BRMS1 antibody (AA 1-246) (ABIN565191)

Target: BRMS1 (Breast Cancer Metastasis Suppressor 1 (BRMS1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This BRMS1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunoprecipitation (IP)

Clone: 2D4-2G11

Product Details anti-BRMS1 Antibody

Binding Specificity: AA 1-246

Purpose: Mouse monoclonal antibody raised against a full length recombinant BRMS1.

Sequence: MPVQPPSKDT EEMEAEGDSA AEMNGEEEES EEERSGSQTE SEEESSEMDD EDYERRRSEC VSEMLDLEKQ FSELKEKLFR ERLSQLRLRL EEVGAERAPE YTEPLGGLQR SLKIRIQVAG IYKGFCLDVI RNKYECELQG AKQHLESEKL LLYDTLQGEL QERIQRLEED RQSLDLSSEW WDDKLHARGS SRSWDSLPPS KRKKAPLVSG PYIVYMLQEI DILEDWTAIK KARAAVSPQK RKSDGP

Cross-Reactivity: Human

Characteristics: Antibody Reactive Against Recombinant Protein.

Immunogen: BRMS1 (AAH09834, 1 a.a. ~ 246 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: In 1x PBS, pH 7.4

Handling Advice: Aliquot to avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

References for anti-BRMS1 antibody (ABIN565191)

Ventura, Quezada, Maloney, Fernandes, Antecka, Martins, Bakalian, di Cesare, Burnier: "Expression of the metastasis suppressor BRMS1 in uveal melanoma." in: Ecancermedicalscience, Vol. 8, pp. 410, (2014) (PubMed).

Liu, Mayo, Nagji, Hall, Shock, Xiao, Stelow, Jones: "BRMS1 suppresses lung cancer metastases through an E3 ligase function on histone acetyltransferase p300." in: Cancer research, Vol. 73, Issue 4, pp. 1308-17, (2013) (PubMed).

Cui, Liu, He, Li, Huang, Sun, Tang, Chen, Jiang, Chen, Yun, Zeng, Guo, Wang, Ma: "Low BRMS1 expression promotes nasopharyngeal carcinoma metastasis in vitro and in vivo and is associated with poor patient survival." in: BMC cancer, Vol. 12, pp. 376, (2012) (PubMed).

Kim, Nam, Pyo, Jang, Kim, Kim, Boo, Lee, Yoon, Baek, Kim: "Breast cancer metastasis suppressor 1 (BRMS1) is destabilized by the Cul3-SPOP E3 ubiquitin ligase complex." in: Biochemical and biophysical research communications, Vol. 415, Issue 4, pp. 720-6, (2011) (PubMed).

Nagji, Liu, Stelow, Stukenborg, Jones: "BRMS1 transcriptional repression correlates with CpG island methylation and advanced pathological stage in non-small cell lung cancer." in: The Journal of pathology, Vol. 221, Issue 2, pp. 229-37, (2010) (PubMed).

Smith, Liu, Siefert, Moskaluk, Petroni, Jones: "Breast cancer metastasis suppressor 1 (BRMS1) suppresses metastasis and correlates with improved patient survival in non-small cell lung cancer." in: Cancer letters, Vol. 276, Issue 2, pp. 196-203, (2009) (PubMed).

Rivera, Megias, Bravo: "Proteomics-based strategy to delineate the molecular mechanisms of the metastasis suppressor gene BRMS1." in: Journal of proteome research, Vol. 6, Issue 10, pp. 4006-18, (2007) (PubMed).

Liu, Smith, Jones: "Breast cancer metastasis suppressor 1 functions as a corepressor by enhancing histone deacetylase 1-mediated deacetylation of RelA/p65 and promoting apoptosis." in: Molecular and cellular biology, Vol. 26, Issue 23, pp. 8683-96, (2006) (PubMed).

Target Details for BRMS1

Target: BRMS1 (Breast Cancer Metastasis Suppressor 1 (BRMS1))

Alternative Name: BRMS1

Background: Full Gene Name: breast cancer metastasis suppressor 1
Synonyms: DKFZp564A063

Gene ID: 25855