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S1PR2 antibody (Internal Region)

S1PR2 Reactivity: Human, Mouse, Rat, Dog WB, EIA Host: Goat Polyclonal unconjugated
Catalog No. ABIN568703
  • Target See all S1PR2 Antibodies
    S1PR2 (Sphingosine-1-Phosphate Receptor 2 (S1PR2))
    Binding Specificity
    • 8
    • 6
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reactivity
    • 28
    • 9
    • 7
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat, Dog
    Host
    • 28
    • 1
    Goat
    Clonality
    • 29
    Polyclonal
    Conjugate
    • 14
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This S1PR2 antibody is un-conjugated
    Application
    • 19
    • 15
    • 5
    • 4
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Enzyme Immunoassay (EIA)
    Sequence
    C-NYTKETLETQ
    Specificity
    Recognizes EDG-5 / S1P2.
    Cross-Reactivity (Details)
    Species reactivity (expected):Dog.
    Species reactivity (tested):Human, Mouse, Rat.
    Purification
    Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide.
    Immunogen
    Peptide with sequence from the internal region of the protein sequence according to NP_004221.3. Genename: S1PR2
    Top Product
    Discover our top product S1PR2 Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Concentration
    0.5 mg/mL
    Buffer
    Tris saline, pH 7.3, 0.02 % Sodium Azide, 0.5 % BSA
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Song, Hou, Chen, Cheng, Lei, Cui, Sun, Wang, Fang: "Sphingosine-1-phosphate Receptor 2 Signaling Promotes Caspase-11-dependent Macrophage Pyroptosis and Worsens Escherichia coli Sepsis Outcome." in: Anesthesiology, Vol. 129, Issue 2, pp. 311-320, (2019) (PubMed).

  • Target
    S1PR2 (Sphingosine-1-Phosphate Receptor 2 (S1PR2))
    Alternative Name
    EDG-5 / S1P2 (S1PR2 Products)
    Synonyms
    AGR16 antibody, EDG-5 antibody, EDG5 antibody, Gpcr13 antibody, H218 antibody, LPB2 antibody, S1P2 antibody, 1100001A16Rik antibody, Edg5 antibody, LPb2 antibody, GPCR18 antibody, snGPCR18 antibody, sphingosine-1-phosphate receptor 2 antibody, S1PR2 antibody, S1pr2 antibody
    Background
    The EDG (endothelial differentiation gene) family of G protein-coupled receptors consists of eight family members that bind lysophospholipid (LPL) mediators, including sphingosine-1-phosphate (SPP) and lysophosphatidic acid (LPA). EDG-1, EDG-3, EDG-5 (also designated H218 and AGR16) and EDG-8 bind SPP with high-affinity. EDG-6 is a low-affinity receptor for SPP. LPA preferentially binds to EDG-2, EDG-4 and EDG-7. The EDG receptors couple to multiple G proteins to signal through Ras, MAP kinase, Rho, Phospholipase C or other tyrosine kinases, which lead to cell survival, growth, migration and differentiation. EDG-1 signals through Gi proteins to activate Akt and is expressed in glioma cells. EDG-2 is expressed in brain, especially in white matter tract regions, while EDG-3 is expressed in cardiovascular tissue and in cerebellum. EDG-4 is highly expressed on leukocytes and brain. EDG-5 has wide tissue distribution, including cardiovascular tissue and brain. Expressed in lymphoid and hematopoietic tissues and in lung, EDG-6 signals through Gi/o proteins, which activate growth related pathways.Synonyms: AGR16, EDG5, Endothelial differentiation G-protein coupled receptor 5, Gpcr13, H218, LPB2, S1P receptor 2, S1PR2, Sphingosine 1-phosphate receptor 2
    Gene ID
    9294
    NCBI Accession
    NP_004221
    UniProt
    O95136
    Pathways
    Synaptic Membrane
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