POR antibody (Internal Region)

Catalog No. ABIN568710

The Goat Polyclonal anti-POR antibody (ABIN568710) specifically detects POR in WB and EIA. The antibody is reactive with Human, Rat, Mouse, Rabbit, Cow, Dog and Pig samples.

Quick Overview for POR antibody (Internal Region) (ABIN568710)

Target: POR (P450 (Cytochrome) Oxidoreductase (POR))

Reactivity: Human, Rat, Mouse, Rabbit, Cow, Dog, Pig

Host: Goat

Clonality: Polyclonal

Conjugate: This POR antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Product Details anti-POR Antibody

Binding Specificity: Internal Region

Sequence: C-TNPPRTNVLY E

Specificity: Recognizes Cytochrome P450 Reductase (CYPOR).

Cross-Reactivity (Details): Species reactivity (expected):Dog, Cow, Pig, Rabbit.
Species reactivity (tested):Human, Mouse, Rat.

Purification: Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide.

Immunogen: Peptide with sequence from the internal region of the protein sequence according to NP_000932.3. Genename: POR

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Tris saline, pH 7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for POR

Target: POR (P450 (Cytochrome) Oxidoreductase (POR))

Alternative Name: Cytochrome P450 Reductase

Background: P450R is an endoplasmic reticulum membrane oxidoreductase with an FAD-binding domain and a flavodoxin-like domain. The protein binds two cofactors, FAD and FMN, which allow it to donate electrons directly from NADPH to all microsomal P450 enzymes. Mutations in its gene have been associated with various diseases, including apparent combined P450C17 and P450C21 deficiency, amenorrhea and disordered steroidogenesis, congenital adrenal hyperplasia and Antley-Bixler syndrome.Synonyms: CPR, CYPOR, NADPH--cytochrome P450 reductase, P450R, POR

Gene ID: 5447

NCBI Accession: NP_000932

UniProt: P16435

Pathways: Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, SARS-CoV-2 Protein Interactome