Snail Homolog 1 (Drosophila) (SNAI1) (N-Term) antibody

Details for Product No. ABIN569652
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Antigen
Synonyms
SNAI1, BG:DS01845.1, CG3956, Dmel\\CG3956, SNA, Sco, Sna, br28, br29, l(2)35Db, l(2)br28, l(2)br29, l(3)br28, l35Db, sn, Xsnail, sna, snail1, xSna, Snai, SLUGH2, SNAH, SNAIL, SNAIL1, dJ710H13.1, AI194 ... show more
SNAI1, BG:DS01845.1, CG3956, Dmel\\CG3956, SNA, Sco, Sna, br28, br29, l(2)35Db, l(2)br28, l(2)br29, l(3)br28, l35Db, sn, Xsnail, sna, snail1, xSna, Snai, SLUGH2, SNAH, SNAIL, SNAIL1, dJ710H13.1, AI194338, Sna1, Snail, Snail1 show less
Epitope
N-Term
(39), (15), (7), (6), (4), (4), (3), (3), (3), (2), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(127), (41), (9), (2), (2), (2)
Host
Goat
(82), (25), (17), (3)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (3), (3), (3), (3), (3)
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(118), (68), (23), (21), (9), (9), (5), (4), (4), (1)
Pubmed 1 reference available
Quantity 0.1 mg
Shipping to United States ( )
Availability Will be delivered in 6 to 8 Business Days
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Immunogen Peptide with sequence from the N Terminus of the protein sequence according to NP_005976.2. Genename: SNAI1
Sequence RKPSDPNRKP NY-C
Specificity Snail homolog 1 / SNAI1
Cross-Reactivity (Details) Species reactivity (expected):Rat.
Species reactivity (tested):Human, Mouse.
Purification Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide
Alternative Name SNAI1 (SNAI1 Antibody Abstract)
Background Zinc finger protein SNAI1 (SNAIL) is a zinc finger transcriptional repressor which down regulates the expression of ectodermal gene within the mesoderm and thus functions to form the mesoderm and neural crest. It is reported that SNAI1 acts as an important factor of tumor invasion as evidenced by its role in E-cadherin down-regulation and induction of epithelial-mesenchymal transition (EMT). In human breast cancer, the expression of SNAI1 and/or the homologous SNAI2 (Slug) has been associated with E-cadherin repression, local or distant metastasis, tumor recurrence, or poor prognosis in different tumor series. It is also reported that Snail 1 protein in the stroma may be a new putative prognosis marker for colon tumors. In recent studies SNAI1 is found to be potential target for proteasome degradation by hypoxia-controlled FBXL14 ubiquitin ligase targets.Synonyms: Protein snail homolog 1, SNAH, Zinc finger protein SNAI1
Gene ID 6615
NCBI Accession NP_005976
UniProt O95863
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 0.5 mg/mL
Buffer Tris saline, pH ~7.3 with 0.02 % Sodium Azide and 0.5 % BSA
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Background publications Vega, Morales, Ocaña et al.: "Snail blocks the cell cycle and confers resistance to cell death." in: Genes & development, Vol. 18, Issue 10, pp. 1131-43, 2004 (PubMed).

Validation Images
Catalog No. ABIN569652
368.50 $
Plus shipping costs $45.00
Quantity
Price
0.1 mg
368.50 $

Order hotline:

  • +1 877 302 8632
  • +1 888 205 9894 (TF)
Did you look for something else?