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Snail Homolog 1 (Drosophila) (SNAI1) (N-Term) antibody

Details for Product No. ABIN569652, Supplier: Log in to see
Antigen
  • SNAI1
  • BG:DS01845.1
  • CG3956
  • Dmel\\CG3956
  • SNA
  • Sco
  • Sna
  • br28
  • br29
  • l(2)35Db
  • l(2)br28
  • l(2)br29
  • l(3)br28
  • l35Db
  • sn
  • Xsnail
  • sna
  • snail1
  • xSna
  • Snai
  • SLUGH2
  • SNAH
  • SNAIL
  • SNAIL1
  • dJ710H13.1
  • AI194338
  • Sna1
  • Snail
  • Snail1
Epitope
N-Term
42
12
7
7
5
4
4
3
3
3
3
2
2
2
2
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
135
40
12
2
2
2
Host
Goat
91
25
16
3
Clonality
Polyclonal
Conjugate
Un-conjugated
3
3
3
3
3
3
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
121
66
25
23
10
10
5
5
1
1
1
1
Supplier
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Immunogen Peptide with sequence from the N Terminus of the protein sequence according to NP_005976.2. Genename: SNAI1
Sequence RKPSDPNRKP NY-C
Specificity Snail homolog 1 / SNAI1
Cross-Reactivity (Details) Species reactivity (expected):Rat.
Species reactivity (tested):Human, Mouse.
Purification Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide
Alternative Name SNAI1 (SNAI1 Antibody Abstract)
Background Zinc finger protein SNAI1 (SNAIL) is a zinc finger transcriptional repressor which down regulates the expression of ectodermal gene within the mesoderm and thus functions to form the mesoderm and neural crest. It is reported that SNAI1 acts as an important factor of tumor invasion as evidenced by its role in E-cadherin down-regulation and induction of epithelial-mesenchymal transition (EMT). In human breast cancer, the expression of SNAI1 and/or the homologous SNAI2 (Slug) has been associated with E-cadherin repression, local or distant metastasis, tumor recurrence, or poor prognosis in different tumor series. It is also reported that Snail 1 protein in the stroma may be a new putative prognosis marker for colon tumors. In recent studies SNAI1 is found to be potential target for proteasome degradation by hypoxia-controlled FBXL14 ubiquitin ligase targets.Synonyms: Protein snail homolog 1, SNAH, Zinc finger protein SNAI1
Gene ID 6615
NCBI Accession NP_005976
UniProt O95863
Pathways
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 0.5 mg/mL
Buffer Tris saline, pH ~7.3 with 0.02 % Sodium Azide and 0.5 % BSA
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Background publications Vega, Morales, Ocaña et al.: "Snail blocks the cell cycle and confers resistance to cell death." in: Genes & development, Vol. 18, Issue 10, pp. 1131-43, 2004 (PubMed).