ELAVL1 antibody

Catalog No. ABIN577055

There are 4+ publications for this product available. The Mouse Monoclonal anti-ELAVL1 antibody is suitable to detect ELAVL1 in samples from Human, Mouse, Rat and Zebrafish (Danio rerio). It has been validated for WB, IHC, ELISA, IP and ChIP.

Quick Overview for ELAVL1 antibody (ABIN577055)

Target: ELAVL1 (ELAV (Embryonic Lethal, Abnormal Vision, Drosophila)-Like 1 (Hu Antigen R) (ELAVL1))

Reactivity: Human, Mouse, Rat, Zebrafish (Danio rerio)

Host: Mouse

Clonality: Monoclonal

Conjugate: This ELAVL1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunoprecipitation (IP), Chromatin Immunoprecipitation (ChIP)

Clone: 19F12

Product Details anti-ELAVL1 Antibody

Specificity: Greater than 95%

Purification: Purified IgG

Purity: > 98 %

Immunogen: Synthetic Peptide

Isotype: IgG1

Application Details

Application Notes: Works on IHC at 1/2000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1mg/ml

Buffer: PBS /glycerol

Storage: -20 °C

References for anti-ELAVL1 antibody (ABIN577055)

Ni, Zhou, Song, Chen, Wang, Du, Zhang: "ELAVL1a is an immunocompetent protein that protects zebrafish embryos from bacterial infection." in: Communications biology, Vol. 4, Issue 1, pp. 251, (2021) (PubMed).

Li, Lu, Dai, Torregroza, Hla, Evans: "Elavl1a regulates zebrafish erythropoiesis via posttranscriptional control of gata1." in: Blood, Vol. 123, Issue 9, pp. 1384-92, (2014) (PubMed).

Chang, Lu, Li, Hsieh, Xiong, Ghosh, Evans, Elemento, Hla: "Antagonistic function of the RNA-binding protein HuR and miR-200b in post-transcriptional regulation of vascular endothelial growth factor-A expression and angiogenesis." in: The Journal of biological chemistry, Vol. 288, Issue 7, pp. 4908-21, (2013) (PubMed).

García-Domínguez, Morello, Cisneros, Kontoyiannis, Frade: "Stabilization of Dll1 mRNA by Elavl1/HuR in neuroepithelial cells undergoing mitosis." in: Molecular biology of the cell, Vol. 22, Issue 8, pp. 1227-39, (2011) (PubMed).

Target Details for ELAVL1

Target: ELAVL1 (ELAV (Embryonic Lethal, Abnormal Vision, Drosophila)-Like 1 (Hu Antigen R) (ELAVL1))

Alternative Name: HuR

Background: HuR (also called Elavl-1 or HuA) is a protein that binds to specific AU-rich elements in a mRNA and thereby upregulates its expression. The protein contains three RRM type RNA binding domains. The first and second RNA binding domains interact with the AU-rich element. HuR is a member of a family of proteins called the elav-like proteins. The other members, HuD, HuC, and HEL-N1 are predominantly expressed in neurons. Monoclonal 19F12 was designed by CLONEGENE and was generated against a unique HuR peptide and does not react with HuD, HuC, or Hel-N1.

Pathways: AMPK Signaling