Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1) antibody (APC)

Details for Product No. ABIN614763
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Antigen
Synonyms
E-Cad, E-cadherin, XB-cadherin, XBcad, XTCAD-1, b-cadherin, cadherin-1, cdh1-a, cdhc-A, cdhp, hjmd, l-cam, lcam, pcad, uvo, uvomorulin, xb-cad, xcdh1, Arc1, AA960649, E-cad, Ecad, L-CAM, UVO, Um, Arc- ... show more
E-Cad, E-cadherin, XB-cadherin, XBcad, XTCAD-1, b-cadherin, cadherin-1, cdh1-a, cdhc-A, cdhp, hjmd, l-cam, lcam, pcad, uvo, uvomorulin, xb-cad, xcdh1, Arc1, AA960649, E-cad, Ecad, L-CAM, UVO, Um, Arc-1, CD324, CDHE, ECAD, LCAM, arc-1, cd324, cdhe, ecad, cdh1, si:dz180o5.2 show less
Reactivity
Human
(330), (102), (75), (29), (27), (21), (17), (15), (14), (14), (6), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Host
Mouse
(228), (143), (9), (5), (3), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
APC
(18), (16), (9), (6), (6), (5), (3), (3), (3), (3), (3), (3), (3), (3)
Application
Flow Cytometry (FACS)
(263), (109), (107), (67), (66), (56), (56), (52), (30), (29), (15), (10), (8), (2), (2), (2), (1), (1)
Pubmed 12 references available
Quantity 100 tests
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
Request Want additional data for this product?

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Catalog No. ABIN614763
412.50 $
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Immunogen T-47D cells
Clone 67A4
Isotype IgG1
Specificity This antibody recognizes CD324 / E-cadherin, an approximately 100 kDa epithelial cell adhesion molecule, whose detection is important for determination of invasive potential of epithelial neoplasms.
Cross-Reactivity (Details) Species reactivity (tested):Human
Alternative Name CD324 / Cadherin-1
Background CD324 / E-cadherin is an epithelial cell surface molecule, which provides calcium-dependent homophilic interactions with E-cadherin of another cell. These intaractions take part in morphogenetic programs controlling the maintenance of the structural and functional integrity of epithelia and affect invasive potential of epithelial neoplasms. CD324 / E-cadherin is implicated in cell growth and differentiation, cell recognition, and sorting during developmental morphogenesis, as well as in aggregation-dependent cell survival. CD324 / E-cadherin-mediated cell adhesion system is highly regulated from inside the cell by a number of intracellular signaling pathways.Synonyms: CAM 120/80, CDH1, CDHE, E-cadherin, Epithelial cadherin, UVO, Uvomorulin
Gene ID 999, 9606
UniProt P12830
Research Area Extracellular Matrix, Signaling, Cytoskeleton
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Buffer Phosphate buffered saline (PBS) containing 15 mM sodium azide and 0.2 % (w/v) high-grade protease free Bovine Serum Albumin (BSA) as a stabilizing agent
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice DO NOT FREEZE! This product is photosensitive and should be protected from light.
Storage 4 °C
Background publications Takeichi: "Cadherin cell adhesion receptors as a morphogenetic regulator." in: Science (New York, N.Y.), Vol. 251, Issue 5000, pp. 1451-5, 1991 (PubMed).

Armeanu, Bühring, Reuss-Borst et al.: "E-cadherin is functionally involved in the maturation of the erythroid lineage." in: The Journal of cell biology, Vol. 131, Issue 1, pp. 243-9, 1995 (PubMed).

Bühring, Müller, Herbst et al.: "The adhesion molecule E-cadherin and a surface antigen recognized by the antibody 9C4 are selectively expressed on erythroid cells of defined maturational stages." in: Leukemia, Vol. 10, Issue 1, pp. 106-16, 1996 (PubMed).

Pece, Chiariello, Murga et al.: "Activation of the protein kinase Akt/PKB by the formation of E-cadherin-mediated cell-cell junctions. Evidence for the association of phosphatidylinositol 3-kinase with the E-cadherin adhesion complex." in: The Journal of biological chemistry, Vol. 274, Issue 27, pp. 19347-51, 1999 (PubMed).

Servet-Delprat, Vidalain, Bausinger et al.: "Measles virus induces abnormal differentiation of CD40 ligand-activated human dendritic cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 164, Issue 4, pp. 1753-60, 2000 (PubMed).

Pece, Gutkind: "Signaling from E-cadherins to the MAPK pathway by the recruitment and activation of epidermal growth factor receptors upon cell-cell contact formation." in: The Journal of biological chemistry, Vol. 275, Issue 52, pp. 41227-33, 2001 (PubMed).

Novak, Kraft, Haberstok et al.: "A reducing microenvironment leads to the generation of FcepsilonRIhigh inflammatory dendritic epidermal cells (IDEC)." in: The Journal of investigative dermatology, Vol. 119, Issue 4, pp. 842-9, 2002 (PubMed).

Kutlesa, Wessels, Speiser et al.: "E-cadherin-mediated interactions of thymic epithelial cells with CD103+ thymocytes lead to enhanced thymocyte cell proliferation." in: Journal of cell science, Vol. 115, Issue Pt 23, pp. 4505-15, 2002 (PubMed).

Robertson, Ali, McDonnell et al.: "Chronic renal allograft dysfunction: the role of T cell-mediated tubular epithelial to mesenchymal cell transition." in: Journal of the American Society of Nephrology : JASN, Vol. 15, Issue 2, pp. 390-7, 2004 (PubMed).

Furio, Guezennec, Ducarre et al.: "Differential effects of allergens and irritants on early differentiating monocyte-derived dendritic cells." in: European journal of dermatology : EJD, Vol. 18, Issue 2, pp. 141-7, 2008 (PubMed).

Caberg, Hubert, Begon et al.: "Silencing of E7 oncogene restores functional E-cadherin expression in human papillomavirus 16-transformed keratinocytes." in: Carcinogenesis, Vol. 29, Issue 7, pp. 1441-7, 2008 (PubMed).

Lin, Liao, Lee et al.: "Molecular events associated with epithelial to mesenchymal transition of nasopharyngeal carcinoma cells in the absence of Epstein-Barr virus genome." in: Journal of biomedical science, Vol. 16, pp. 105, 2009 (PubMed).

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