PAFAH1B1 antibody (C-Term)

Catalog No. ABIN614917

This Goat Polyclonal antibody specifically detects PAFAH1B1 in WB, IHC (p) and EIA. It exhibits reactivity toward Human, Rat, Mouse, Cow, Dog and Pig.

Quick Overview for PAFAH1B1 antibody (C-Term) (ABIN614917)

Target: PAFAH1B1 (Platelet-Activating Factor Acetylhydrolase 1b, Regulatory Subunit 1 (45kDa) (PAFAH1B1))

Reactivity: Human, Rat, Mouse, Cow, Dog, Pig

Host: Goat

Clonality: Polyclonal

Conjugate: This PAFAH1B1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Product Details anti-PAFAH1B1 Antibody

Binding Specificity: C-Term

Sequence: TGSVDQTVKV WECR

Specificity: This antibody detects PAFAH1B1 / LIS1.

Cross-Reactivity (Details): Species reactivity (expected):Cow, Dog, Mouse, Pig, RatSpecies reactivity (tested):Human

Purification: Immunoaffinity chromatography

Immunogen: Peptide from (C-term) of the protein sequence according to NP_000421. Genename: PAFAH1B1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Tris buffered saline, 0.5 % BSA, 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.

Target Details for PAFAH1B1

Target: PAFAH1B1 (Platelet-Activating Factor Acetylhydrolase 1b, Regulatory Subunit 1 (45kDa) (PAFAH1B1))

Alternative Name: PAFAH1B1 / LIS1

Background: PAFAH1B1 was identified as encoding a gene that when mutated or lost caused the lissencephaly associated with Miller-Dieker lissencephaly syndrome. PAFAH1B1 encodes the non-catalytic alpha subunit of the intracellular Ib isoform of platelet-activating factor acteylhydrolase, a heterotrimeric enzyme that specifically catalyzes the removal of the acetyl group at the SN-2 position of platelet-activating factor (identified as 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine). Two other isoforms of intracellular platelet-activating factor acetylhydrolase exist: one composed of multiple subunits, the other, a single subunit. In addition, a single-subunit isoform of this enzyme is found in serum.Synonyms: LIS-1, Lissencephaly-1 protein, MDCR, MDS, PAF acetylhydrolase 45 kDa subunit, PAF-AH alpha, PAFAH alpha, PAFAHA, Platelet-activating factor acetylhydrolase IB subunit alpha

Gene ID: 5048

NCBI Accession: NP_000421

UniProt: P43034

Pathways: M Phase, Regulation of Cell Size