KCNJ11 antibody (Internal Region)

Catalog No. ABIN614945

The Goat Polyclonal anti-KCNJ11 antibody is suitable to detect KCNJ11 in samples from Human, Mouse, Rat and Dog. It has been validated for WB, IHC (p) and EIA.

Quick Overview for KCNJ11 antibody (Internal Region) (ABIN614945)

Target: KCNJ11 (Potassium Inwardly-Rectifying Channel, Subfamily J, Member 11 (KCNJ11))

Reactivity: Human, Mouse, Rat, Dog

Host: Goat

Clonality: Polyclonal

Conjugate: This KCNJ11 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Product Details anti-KCNJ11 Antibody

Binding Specificity: Internal Region

Sequence: ERRARFVSKK GNC

Cross-Reactivity (Details): Species reactivity (expected):Dog, Mouse, RatSpecies reactivity (tested):Human

Purification: Immunoaffinity chromatography

Immunogen: Synthetic peptide from an internal region of human Kcnj11 Genename: KCNJ11

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Tris saline buffer, pH 7.3, 0.5 % BSA, 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.

Target Details for KCNJ11

Target: KCNJ11 (Potassium Inwardly-Rectifying Channel, Subfamily J, Member 11 (KCNJ11))

Alternative Name: KCNJ11

Background: Kir6.2/Kcnj11, an ATP sensitive inwardly-rectifying potassium channel, was originally isolated from an insulinoma library. Actual conductance requires association with the sulfonylurea receptor. This receptor is inhibited by sulfonylureas and activated by diazoxide. Mutations in the KNCJ11 gene are found in patients with permanent diabetes mellitus of infancy and hyperinsulinemic hypoglycemia. It is thought that this channel couples metabolism to membrane electrical events fibringing about insulin secretion.Synonyms: ATP-sensitive inward rectifier potassium channel 11, IKATP, Inward rectifier K+ channel Kir6.2, KCNJ11, Potassium channel, inwardly rectifying subfamily J member 11

Gene ID: 9606

UniProt: Q14654

Pathways: Negative Regulation of Hormone Secretion