APAF1 antibody (C-Term)

Catalog No. ABIN5611436

This Rabbit Polyclonal antibody specifically detects APAF1 in IHC (p). It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for APAF1 antibody (C-Term) (ABIN5611436)

Target: APAF1 (Apoptotic Peptidase Activating Factor 1 (APAF1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This APAF1 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-APAF1 Antibody

Binding Specificity: C-Term

Specificity: This antibody reacts to Apoptotic Protease Activating Factor 1 (APAF1).

Purification: Immunoaffinity Chromatography

Immunogen: APAF1 antibody was raised against a synthetic peptide derived from the C-terminus of human Apaf-1 Genename: APAF1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: 10 mM PBS, pH 7.4, BSA, sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store the antibody undiluted at 2-8 °C. DO NOT FREEZE!

Target Details for APAF1

Target: APAF1 (Apoptotic Peptidase Activating Factor 1 (APAF1))

Alternative Name: APAF1

Background: Apaf1 has been described as the core of the apoptosome. Deficiency in murine Apaf1 leads to embryonic lethality with a phenotype affecting many aspects of developmental apoptosis. In the developing brain, Apaf1 is a death regulator of the neuronal founder cells. Combined intercrosses of mouse lines mutant for members of the mitochondrial death pathway are providing us with some clues about the relative regulation existing among neuronal cell populations. Apaf1-deficient embryos display an interesting phenotype in the inner ear and in limb development, which involves different caspase-dependent and -independent pathways. Moreover, APAF1 is mutated in human melanomas, and its depletion contributes to malignant transformation in a mouse model of cancer.Synonyms: Apaf-1, Apoptotic protease-activating factor 1, KIAA0413

Gene ID: 317

NCBI Accession: NP_001151

UniProt: O14727

Pathways: p53 Signaling, Apoptosis, Caspase Cascade in Apoptosis, Tube Formation, Positive Regulation of Endopeptidase Activity