XIAP antibody (AA 75-226)

Catalog No. ABIN615851

The Rabbit Polyclonal anti-XIAP antibody is suitable to detect XIAP in samples from Human. It has been validated for WB, IF and IHC (p).

Quick Overview for XIAP antibody (AA 75-226) (ABIN615851)

Target: XIAP (X-Linked Inhibitor of Apoptosis (XIAP))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This XIAP antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-XIAP Antibody

Binding Specificity: AA 75-226

Specificity: This antibody reacts to X-linked Inhibitor Of Apoptosis Protein XIAP (XIAP/BIRC4).

Cross-Reactivity (Details): Species reactivity (expected):Mouse (88 %), Rat (90 %), Rabbit (94 %), Pig (92 %).
Species reactivity (tested):Human.

Purification: Immunoaffinity Chromatography

Immunogen: Recombinant protein fragment containing a sequence corresponding to a region within amino acids 75 and 226 of BIRC4. Genename: XIAP

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: 0.1 M Tris-Glycine, pH 7.0 containing 10 % Glycerol and 0.01 % Thimerosal

Preservative: Thimerosal (Merthiolate)

Precaution of Use: This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Target Details for XIAP

Target: XIAP (X-Linked Inhibitor of Apoptosis (XIAP))

Alternative Name: IAP3 / BIRC4

Background: Apoptosis inhibitor 3 (API3) is a member of a family of proteins which inhibit apoptosis through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2. Similar to API1, API3 inhibits apoptosis induced by menadione, a potent inducer of free radicals, and ICE. API3 also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7.Synonyms: API3, Baculoviral IAP repeat-containing protein 4, E3 ubiquitin-protein ligase XIAP, HILP, Inhibitor of apoptosis protein 3, X-linked IAP, X-linked inhibitor of apoptosis protein, XIAP

Gene ID: 331

NCBI Accession: NP_001158

UniProt: P98170

Pathways: Apoptosis, Caspase Cascade in Apoptosis, Transition Metal Ion Homeostasis