P2RX1 antibody (Middle Region)

Catalog No. ABIN630119

The Rabbit Polyclonal anti-P2RX1 antibody is suitable to detect P2RX1 in samples from Human and Dog. It has been validated for WB and IHC.

Quick Overview for P2RX1 antibody (Middle Region) (ABIN630119)

Target: P2RX1 (Purinergic Receptor P2X, Ligand Gated Ion Channel 1 (P2RX1))

Reactivity: Human, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This P2RX1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-P2RX1 Antibody

Binding Specificity: Middle Region

Specificity: P2 RX1 antibody was raised against the middle region of P2 X1

Purification: Purified

Immunogen: P2 RX1 antibody was raised using the middle region of P2 X1 corresponding to a region with amino acids VVGITIDWHCDLDWHVRHCRPIYEFHGLYEEKNLSPGFNFRFARHFVENG

Application Details

Application Notes: WB: 2.5 µg/mL, IHC: 4-8 µg/mL
Optimal conditions should be determined by the investigator.

Comment:

P2RX1 Blocking Peptide, (ABIN5615161), is also available for use as a blocking control in assays to test for specificity of this P2RX1 antibody

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Lyophilized powder. Add distilled water for a 1 mg/mL concentration of P0 X1 antibody in PBS

Concentration: Lot specific

Buffer: PBS

Handling Advice: Avoid repeated freeze/thaw cycles.
Dilute only prior to immediate use.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2-8 °C for short periods. For longer periods of storage, store at -20 °C.

Target Details for P2RX1

Target: P2RX1 (Purinergic Receptor P2X, Ligand Gated Ion Channel 1 (P2RX1))

Alternative Name: P2RX1

Background: P2RX1 belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel with relatively high calcium permeability. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle, being responsible, for example, for sympathetic vasoconstriction in small arteries, arterioles and vas deferens. Mouse studies suggest that this receptor is essential for normal male reproductive function. It is possible that the development of selective antagonists for this receptor may provide an effective non-hormonal male contraceptive pill.

Molecular Weight: 45 kDa (MW of target protein)

Pathways: Positive Regulation of Endopeptidase Activity