PADI2 antibody (Middle Region)

Catalog No. ABIN631162

This Rabbit Polyclonal antibody specifically detects PADI2 in WB. It exhibits reactivity toward Human.

Quick Overview for PADI2 antibody (Middle Region) (ABIN631162)

Target: PADI2 (Peptidyl Arginine Deiminase, Type II (PADI2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PADI2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PADI2 Antibody

Binding Specificity: Middle Region

Specificity: PADI2 antibody was raised against the middle region of PADI2

Purification: Affinity purified

Immunogen: PADI2 antibody was raised using the middle region of PADI2 corresponding to a region with amino acids RGDRWIQDEIEFGYIEAPHKGFPVVLDSPRDGNLKDFPVKELLGPDFGYV

Application Details

Application Notes: WB: 0.5 µg/mL
Optimal conditions should be determined by the investigator.

Comment:

PADI2 Blocking Peptide, (ABIN5615187), is also available for use as a blocking control in assays to test for specificity of this PADI2 antibody

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Lyophilized powder. Add distilled water for a 1 mg/mL concentration of PADI2 antibody in PBS

Concentration: Lot specific

Buffer: PBS

Handling Advice: Avoid repeated freeze/thaw cycles.
Dilute only prior to immediate use.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2-8 °C for short periods. For longer periods of storage, store at -20 °C.

Target Details for PADI2

Target: PADI2 (Peptidyl Arginine Deiminase, Type II (PADI2))

Alternative Name: PADI2

Background: PADI2 encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type II enzyme is the most widely expressed family member. Known substrates for this enzyme include myelin basic protein in the central nervous system and vimentin in skeletal muscle and macrophages. PADI2 is thought to play a role in the onset and progression of neurodegenerative human disorders, including Alzheimer disease and multiple sclerosis, and it has also been implicated in glaucoma pathogenesis.

Molecular Weight: 75 kDa (MW of target protein)