Lysosomal-Associated Membrane Protein 1 (LAMP1) antibody (PE)

Antigen: Lysosomal-Associated Membrane Protein 1 (LAMP1)

Synonyms: LAMPA, CD107a, LGP120

Clonality: Monoclonal (H4A3)

Host: Please enquire

Reactivity: Human, Primate, Mouse (Murine)

Conjugate: PE

Application: Flow Cytometry (FACS), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC)

Catalog no.: ABIN638446

Additional Information

Alternative name: CD107a

Gene ID: 3916

Immunogen: Human PBMC

Isotype: IgG1

Clone: H4A3

Specificity: The mouse monoclonal antibody H4A3 recognizes CD107a, an approximately 100-120 kDa glycoprotein expressed mainly on lysosomal, but also on the plasma membrane.

Application Details

Buffer: The reagent is provided in phosphate buffered saline (PBS) containing 0.02% sodium azide, 0.2% (w/v) high-grade protease free Bovine Serum Albumin (BSA) as a stabilizing agent.

Storage: Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light.Do not use after expiration date stamped on vial label. Short-term exposure to room temperature should not affect the quality of the reagent. However, if reagent is stored under any conditions other than those specified, the conditions must be verified by the user.

Research Area: CD Antigens

Restrictions: For Research Use only

Publications

Product: Mane, Marzella, Bainton et al.: "Purification and characterization of human lysosomal membrane glycoproteins." in: Archives of biochemistry and biophysics, Vol. 268, Issue 1, pp. 360-78, 1989 (PubMed).

Furuta, Ikeda, Nakayama et al.: "Expression of lysosome-associated membrane proteins in human colorectal neoplasms and inflammatory diseases." in: The American journal of pathology, Vol. 159, Issue 2, pp. 449-55, 2001 (PubMed).

Marcenaro, Gallo, Martini et al.: "Analysis of natural killer-cell function in familial hemophagocytic lymphohistiocytosis (FHL): defective CD107a surface expression heralds Munc13-4 defect and discriminates between genetic subtypes of the disease." in: Blood, Vol. 108, Issue 7, pp. 2316-23, 2006 (PubMed).

Deetz, Hebbeler, Propp et al.: "Gamma interferon secretion by human Vgamma2Vdelta2 T cells after stimulation with antibody against the T-cell receptor plus the Toll-Like receptor 2 agonist Pam3Cys." in: Infection and immunity, Vol. 74, Issue 8, pp. 4505-11, 2006 (PubMed).

Carlsten, Björkström, Norell et al.: "DNAX accessory molecule-1 mediated recognition of freshly isolated ovarian carcinoma by resting natural killer cells." in: Cancer research, Vol. 67, Issue 3, pp. 1317-25, 2007 (PubMed).

Tomescu, Chehimi, Maino et al.: "NK cell lysis of HIV-1-infected autologous CD4 primary T cells: requirement for IFN-mediated NK activation by plasmacytoid dendritic cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 179, Issue 4, pp. 2097-104, 2007 (PubMed).

Yu, Gallegos, Marches et al.: "Broad influenza-specific CD8+ T-cell responses in humanized mice vaccinated with influenza virus vaccines." in: Blood, Vol. 112, Issue 9, pp. 3671-8, 2008 (PubMed).

Mao, Tu, Liu et al.: "Inhibition of human natural killer cell activity by influenza virions and hemagglutinin." in: Journal of virology, Vol. 84, Issue 9, pp. 4148-57, 2010 (PubMed).