TLR7 antibody

Catalog No. ABIN639907

This Mouse Monoclonal antibody specifically detects TLR7 in WB and ELISA. It exhibits reactivity toward Human.

Quick Overview for TLR7 antibody (ABIN639907)

Target: TLR7 (Toll-Like Receptor 7 (TLR7))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TLR7 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-TLR7 Antibody

Purpose: Mouse Anti-Human TLR7

Specificity: DS-MB-03427 specifically recognizes human TLR7 (toll-like receptor 7), a 121 kDa type I transmembrane protein which belongs to the toll-like receptor (TLR) family, and is predominantly expressed in the spleen, lung and placenta. TLRs are highly conserved proteins which play a key role in activation of innate immunity, through the recognition of distinct molecular patterns expressed by infectious agents. TLR7 recognizes and interacts with single-stranded RNA (ssRNA) derived from viruses such as influenza , HIV-1 (human immunodeficiency virus type I) and Sendai, and some siRNAs, resulting in the activation of the MyD88/interleukin-1 receptor-associated kinase (IRAK) signaling pathway, and the production of proinflammatory signaling molecules.

Purification: Purified

Immunogen: Recombinant human TLR7 (amino acids 451-500) purified from Escherichia coli.

Isotype: IgG1

Application Details

Application Notes: ELISA (dilution: 1/1000, 1/2000), Western Blotting

Restrictions: For Research Use only

Handling

Concentration: IgG concentration 1.0 mg/ml

Buffer: Phosphate buffered saline pH7.4

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: -20°C

Target Details for TLR7

Target: TLR7 (Toll-Like Receptor 7 (TLR7))

Alternative Name: TLR7

Pathways: TLR Signaling, Activation of Innate immune Response, Toll-Like Receptors Cascades