CD11c antibody

Catalog No. ABIN643509

The Rabbit Polyclonal anti-CD11c antibody (ABIN643509) specifically detects CD11c in IHC (p). The antibody is reactive with Human samples.

Quick Overview for CD11c antibody (ABIN643509)

Target: CD11c (ITGAX) (Integrin, alpha X (Complement Component 3 Receptor 4 Subunit) (ITGAX))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CD11c antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-CD11c Antibody

Purpose: Rabbit Anti-Human CD11c

Specificity: DS-PB-00396 detects human CD11c, also known as integrin alpha X (ITGAX). Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. CD11c combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4). CD11c is 150kD in size, and is expressed predominantly on tissue macrophages and dendritic cells. CD11c binds a myriad of ligands including cell adhesion molecules (e.g. ICAM-1, ICAM-4), bacterial cell wall components (LPS), complement protein (iC3b), and matrix proteins such as fibrogen and collagen. In light of this, CD11c has a number of functions including phagocytosis, cell migration, and cytokine production by macrophages/monocytes, as well as induction of T cell proliferation by Langerhans cells.

Characteristics: Adhesion Molecule/Cell Surface

Purification: Purified

Immunogen: Antisera to CD11c were raised by repeated immunisations of rabbit with highly purified antigen. Purified IgG prepared by affinity chromatography.

Isotype: IgG

Application Details

Application Notes: Immunohistology - Paraffin

Restrictions: For Research Use only

Handling

Concentration: IgG concentration 1.0 mg/ml

Buffer: Phosphate buffered saline pH7.7

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: -20°C

Target Details for CD11c

Target: CD11c (ITGAX) (Integrin, alpha X (Complement Component 3 Receptor 4 Subunit) (ITGAX))

Alternative Name: CD11c

Pathways: Complement System, Activated T Cell Proliferation, Integrin Complex